Simultaneous determination of various pharmaceutical compounds in water by solid-phase extraction-liquid chromatography-tandem mass spectrometry

Zhang, ZL; Zhou, JL

Simultaneous determination of various pharmaceutical compounds in water by solid-phase extraction-liquid chromatography-tandem mass spectrometry

Zhang, ZL Zhou, JL

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Publication Type:: Journal Article
Citation:: Journal of Chromatography A, 2007, 1154 (1-2), pp. 205 - 213
Issue Date:: 2007-06-22

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Field	Value	Language
dc.contributor.author	Zhang, ZL	en_US
dc.contributor.author	Zhou, JL https://orcid.org/0000-0003-1393-1608	en_US
dc.date.available	2007-03-21	en_US
dc.date.issued	2007-06-22	en_US
dc.identifier.citation	Journal of Chromatography A, 2007, 1154 (1-2), pp. 205 - 213	en_US
dc.identifier.issn	0021-9673	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28396
dc.description.abstract	A solid-phase extraction (SPE) followed by liquid chromatography-electrospray ionisation tandem mass spectrometry (LC-ESI-MS-MS) method was developed and validated for simultaneous analysis of 11 pharmaceutical residues (propranolol, sulfamethoxazole, meberverine, thioridazine, carbamazepine, tamoxifen, mecoprop, indomethacine, diclofenac, meclofenamic acid and monensin) in environmental water samples. The collision energy chosen for the multiple reaction monitoring (MRM) experiment was optimised. A number of parameters that may affect the recovery of the pharmaceuticals, such as the type of SPE cartridges, eluents, as well as water properties including pH value, salinity and concentration of colloid and surfactant were investigated. It is shown that the Oasis HLB SPE cartridge produced the best recoveries of the target pharmaceuticals while methanol was efficient in eluting pharmaceuticals from SPE cartridges. The recovery of some target compounds was enhanced with increasing salinity, but reduced by increasing pH value, and unaffected by surfactant concentration (0-10 μg/l). The recovery of most compounds was slightly increased by the presence of colloids (0-10 mg/l), which however caused a reduction in recovery for sulfamethoxazole and meberverine. The optimised method was further verified by performing spiking experiments in river water and seawater matrices, with good recovery and reproducibility for all except two compounds. The established method was successfully applied to environmental water samples from East Sussex, UK, for the determination of the target pharmaceuticals. © 2007 Elsevier B.V. All rights reserved.	en_US
dc.relation.ispartof	Journal of Chromatography A	en_US
dc.relation.isbasedon	10.1016/j.chroma.2007.03.105	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.subject.mesh	Pharmaceutical Preparations	en_US
dc.subject.mesh	Colloids	en_US
dc.subject.mesh	Solvents	en_US
dc.subject.mesh	Surface-Active Agents	en_US
dc.subject.mesh	Water Pollutants, Chemical	en_US
dc.subject.mesh	Chromatography, Liquid	en_US
dc.subject.mesh	Spectrometry, Mass, Electrospray Ionization	en_US
dc.subject.mesh	Hydrogen-Ion Concentration	en_US
dc.subject.mesh	Tandem Mass Spectrometry	en_US
dc.subject.mesh	Solid Phase Extraction	en_US
dc.title	Simultaneous determination of various pharmaceutical compounds in water by solid-phase extraction-liquid chromatography-tandem mass spectrometry	en_US
dc.type	Journal Article
utslib.citation.volume	1-2	en_US
utslib.citation.volume	1154	en_US
utslib.for	0904 Chemical Engineering	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	09 Engineering	en_US
utslib.for	10 Technology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	closed_access
pubs.issue	1-2	en_US
pubs.publication-status	Published	en_US
pubs.volume	1154	en_US

Abstract:

A solid-phase extraction (SPE) followed by liquid chromatography-electrospray ionisation tandem mass spectrometry (LC-ESI-MS-MS) method was developed and validated for simultaneous analysis of 11 pharmaceutical residues (propranolol, sulfamethoxazole, meberverine, thioridazine, carbamazepine, tamoxifen, mecoprop, indomethacine, diclofenac, meclofenamic acid and monensin) in environmental water samples. The collision energy chosen for the multiple reaction monitoring (MRM) experiment was optimised. A number of parameters that may affect the recovery of the pharmaceuticals, such as the type of SPE cartridges, eluents, as well as water properties including pH value, salinity and concentration of colloid and surfactant were investigated. It is shown that the Oasis HLB SPE cartridge produced the best recoveries of the target pharmaceuticals while methanol was efficient in eluting pharmaceuticals from SPE cartridges. The recovery of some target compounds was enhanced with increasing salinity, but reduced by increasing pH value, and unaffected by surfactant concentration (0-10 μg/l). The recovery of most compounds was slightly increased by the presence of colloids (0-10 mg/l), which however caused a reduction in recovery for sulfamethoxazole and meberverine. The optimised method was further verified by performing spiking experiments in river water and seawater matrices, with good recovery and reproducibility for all except two compounds. The established method was successfully applied to environmental water samples from East Sussex, UK, for the determination of the target pharmaceuticals. © 2007 Elsevier B.V. All rights reserved.

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http://hdl.handle.net/10453/28396