Vitamin D deficiency in northern Vietnam: Prevalence, risk factors and associations with bone mineral density

Nguyen, HTT; von Schoultz, B; Nguyen, TV; Dzung, DN; Duc, PTM; Thuy, VT; Hirschberg, AL

Vitamin D deficiency in northern Vietnam: Prevalence, risk factors and associations with bone mineral density

Nguyen, HTT von Schoultz, B Nguyen, TV

Dzung, DN Duc, PTM Thuy, VT Hirschberg, AL

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Publication Type:: Journal Article
Citation:: Bone, 2012, 51 (6), pp. 1029 - 1034
Issue Date:: 2012-12-01

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Field	Value	Language
dc.contributor.author	Nguyen, HTT	en_US
dc.contributor.author	von Schoultz, B	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.contributor.author	Dzung, DN	en_US
dc.contributor.author	Duc, PTM	en_US
dc.contributor.author	Thuy, VT	en_US
dc.contributor.author	Hirschberg, AL	en_US
dc.date.available	2012-07-05	en_US
dc.date.issued	2012-12-01	en_US
dc.identifier.citation	Bone, 2012, 51 (6), pp. 1029 - 1034	en_US
dc.identifier.issn	8756-3282	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28725
dc.description.abstract	Purpose: Vitamin D deficiency has been linked to osteoporosis and also to the risk of cancer, autoimmune disorders and cardiovascular diseases. This study sought to determine the prevalence of, and risk factors for, vitamin D deficiency and its relationship with bone mineral density (BMD) in a Vietnamese population. Methods: This cross-sectional study involved 269 women and 222 men aged 13-83. years, who were randomly selected from urban and rural areas in northern Vietnam. Serum concentrations of 25-hydroxy-vitamin D [25(OH)D] and parathyroid hormone (PTH) were measured by electrochemiluminescence immunoassay. Vitamin D deficiency was defined as serum 25(OH)D levels below 20. ng/mL. BMD was measured by dual X-ray absorptiometry. Results: The prevalence of vitamin D deficiency in women was 30%, almost two-fold higher than in men (16%). Significant predictors of vitamin D deficiency in women were urban residency (p < 0.01) and age less than 30. years (p < 0.01), whereas use of contraceptive pills was protective (p < 0.01). In men, winter season was the only significant predictor of vitamin D deficiency (p < 0.01). In multiple linear regression analysis, serum levels of 25(OH)D were positively associated with BMD in both women (p < 0.001) and men (p < 0.001). Conclusions: These data suggest that the prevalence of vitamin D deficiency is high in the Vietnamese population, and that part of this prevalence could be explained by low exposure to sunlight (urban residency and winter season). The high prevalence of vitamin D deficiency should raise the awareness of potentially important health issues such as osteoporosis within the Vietnamese society. © 2012 Elsevier Inc.	en_US
dc.relation.ispartof	Bone	en_US
dc.relation.isbasedon	10.1016/j.bone.2012.07.023	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Vitamin D Deficiency	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Cross-Sectional Studies	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Vietnam	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Young Adult	en_US
dc.title	Vitamin D deficiency in northern Vietnam: Prevalence, risk factors and associations with bone mineral density	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	51	en_US
utslib.for	110306 Endocrinology	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	09 Engineering	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	51	en_US

Abstract:

Purpose: Vitamin D deficiency has been linked to osteoporosis and also to the risk of cancer, autoimmune disorders and cardiovascular diseases. This study sought to determine the prevalence of, and risk factors for, vitamin D deficiency and its relationship with bone mineral density (BMD) in a Vietnamese population. Methods: This cross-sectional study involved 269 women and 222 men aged 13-83. years, who were randomly selected from urban and rural areas in northern Vietnam. Serum concentrations of 25-hydroxy-vitamin D [25(OH)D] and parathyroid hormone (PTH) were measured by electrochemiluminescence immunoassay. Vitamin D deficiency was defined as serum 25(OH)D levels below 20. ng/mL. BMD was measured by dual X-ray absorptiometry. Results: The prevalence of vitamin D deficiency in women was 30%, almost two-fold higher than in men (16%). Significant predictors of vitamin D deficiency in women were urban residency (p < 0.01) and age less than 30. years (p < 0.01), whereas use of contraceptive pills was protective (p < 0.01). In men, winter season was the only significant predictor of vitamin D deficiency (p < 0.01). In multiple linear regression analysis, serum levels of 25(OH)D were positively associated with BMD in both women (p < 0.001) and men (p < 0.001). Conclusions: These data suggest that the prevalence of vitamin D deficiency is high in the Vietnamese population, and that part of this prevalence could be explained by low exposure to sunlight (urban residency and winter season). The high prevalence of vitamin D deficiency should raise the awareness of potentially important health issues such as osteoporosis within the Vietnamese society. © 2012 Elsevier Inc.

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http://hdl.handle.net/10453/28725