Reference Ranges for Bone Mineral Density and Prevalence of Osteoporosis in Vietnamese Men and Women

Ho-Pham, LT; T Nguyen, UD; Pham, HN; Nguyen, ND; Nguyen, TV

Reference Ranges for Bone Mineral Density and Prevalence of Osteoporosis in Vietnamese Men and Women

Ho-Pham, LT T Nguyen, UD Pham, HN Nguyen, ND Nguyen, TV

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Publication Type:: Journal Article
Citation:: BMC Musculoskeletal Disorders, 2011, 12
Issue Date:: 2011-08-12

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Field	Value	Language
dc.contributor.author	Ho-Pham, LT	en_US
dc.contributor.author	T Nguyen, UD	en_US
dc.contributor.author	Pham, HN	en_US
dc.contributor.author	Nguyen, ND	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.date.available	2011-08-10	en_US
dc.date.issued	2011-08-12	en_US
dc.identifier.citation	BMC Musculoskeletal Disorders, 2011, 12	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28730
dc.description.abstract	Background: The aim of this study was to examine the effect of different reference ranges in bone mineral density on the diagnosis of osteoporosis. Methods. This cross-sectional study involved 357 men and 870 women aged between 18 and 89 years, who were randomly sampled from various districts within Ho Chi Minh City, Vietnam. BMD at the femoral neck, lumbar spine and whole body was measured by DXA (Hologic QDR4500). Polynomial regression models and bootstraps method were used to determine peak BMD and standard deviation (SD). Based on the two parameters, we computed T-scores (denoted by T VN) for each individual in the study. A similar diagnosis was also done based on T-scores provided by the densitometer (T DXA), which is based on the US White population (NHANES III). We then compared the concordance between T VNand T DXAin the classification of osteoporosis. Osteoporosis was defined according to the World Health Organization criteria. Results: In post-menopausal women, the prevalence of osteoporosis based on femoral neck T VNwas 29%, but when the diagnosis was based on T DXA, the prevalence was 44%. In men aged 50+ years, the T VN-based prevalence of osteoporosis was 10%, which was lower than T DXA-based prevalence (30%). Among 177 women who were diagnosed with osteoporosis by T DXA, 35% were actually osteopenia by T VN. The kappa-statistic was 0.54 for women and 0.41 for men. Conclusion: These data suggest that the T-scores provided by the Hologic QDR4500 over-diagnosed osteoporosis in Vietnamese men and women. This over-diagnosis could lead to over-treatment and influence the decision of recruitment of participants in clinical trials. © 2011 Ho-Pham et al; licensee BioMed Central Ltd.	en_US
dc.relation.ispartof	BMC Musculoskeletal Disorders	en_US
dc.relation.isbasedon	10.1186/1471-2474-12-182	en_US
dc.subject.classification	Orthopedics	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Osteoporosis	en_US
dc.subject.mesh	Osteoporosis, Postmenopausal	en_US
dc.subject.mesh	Absorptiometry, Photon	en_US
dc.subject.mesh	Prevalence	en_US
dc.subject.mesh	Cross-Sectional Studies	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Reference Values	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Asian Continental Ancestry Group	en_US
dc.subject.mesh	Vietnam	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Young Adult	en_US
dc.title	Reference Ranges for Bone Mineral Density and Prevalence of Osteoporosis in Vietnamese Men and Women	en_US
dc.type	Journal Article
utslib.citation.volume	12	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	12	en_US

Abstract:

Background: The aim of this study was to examine the effect of different reference ranges in bone mineral density on the diagnosis of osteoporosis. Methods. This cross-sectional study involved 357 men and 870 women aged between 18 and 89 years, who were randomly sampled from various districts within Ho Chi Minh City, Vietnam. BMD at the femoral neck, lumbar spine and whole body was measured by DXA (Hologic QDR4500). Polynomial regression models and bootstraps method were used to determine peak BMD and standard deviation (SD). Based on the two parameters, we computed T-scores (denoted by T VN) for each individual in the study. A similar diagnosis was also done based on T-scores provided by the densitometer (T DXA), which is based on the US White population (NHANES III). We then compared the concordance between T VNand T DXAin the classification of osteoporosis. Osteoporosis was defined according to the World Health Organization criteria. Results: In post-menopausal women, the prevalence of osteoporosis based on femoral neck T VNwas 29%, but when the diagnosis was based on T DXA, the prevalence was 44%. In men aged 50+ years, the T VN-based prevalence of osteoporosis was 10%, which was lower than T DXA-based prevalence (30%). Among 177 women who were diagnosed with osteoporosis by T DXA, 35% were actually osteopenia by T VN. The kappa-statistic was 0.54 for women and 0.41 for men. Conclusion: These data suggest that the T-scores provided by the Hologic QDR4500 over-diagnosed osteoporosis in Vietnamese men and women. This over-diagnosis could lead to over-treatment and influence the decision of recruitment of participants in clinical trials. © 2011 Ho-Pham et al; licensee BioMed Central Ltd.

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http://hdl.handle.net/10453/28730