Association between beta-blocker use and fracture risk: The Dubbo Osteoporosis Epidemiology Study

Yang, S; Nguyen, ND; Center, JR; Eisman, JA; Nguyen, TV

Association between beta-blocker use and fracture risk: The Dubbo Osteoporosis Epidemiology Study

Yang, S Nguyen, ND Center, JR Eisman, JA Nguyen, TV

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Publication Type:: Journal Article
Citation:: Bone, 2011, 48 (3), pp. 451 - 455
Issue Date:: 2011-03-01

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Field	Value	Language
dc.contributor.author	Yang, S	en_US
dc.contributor.author	Nguyen, ND	en_US
dc.contributor.author	Center, JR	en_US
dc.contributor.author	Eisman, JA	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.date.available	2010-10-18	en_US
dc.date.issued	2011-03-01	en_US
dc.identifier.citation	Bone, 2011, 48 (3), pp. 451 - 455	en_US
dc.identifier.issn	8756-3282	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28732
dc.description.abstract	Introduction: In animal model, mice treated with beta-blockers (BB) had increased bone mass. In humans, high bone mass is associated with reduce fracture risk. The present study sought to test the hypothesis that BB use is associated with reduced fracture risk. Materials and methods: Data from 3488 participants (1285 men) aged 50. years and above in the Dubbo Osteoporosis Epidemiology Study (DOES) were analyzed. Baseline characteristics of participants were obtained at the initial visit which had taken place between 1989 and 1993. Bone mineral density (BMD) at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry (GE-LUNAR Corp, Madison, WI). Two hundred and sixty two (20%) men and 411 (19%) women had been on BB, as ascertained by direct interview and verification with medication history. The incidence of fragility fractures was ascertained during the follow-up period (1989-2008). Results: In men, BB use was associated with higher BMD at the femoral neck (0.96 versus 0.92g/cm2, P<0.01), higher lumbar spine (1.32 versus 1.25g/cm2, P<0.01), and lower fracture risk than those not on BB (odds ratio [OR]: 0.49; 95% CI: 0.32-0.75). In women, BB users also had higher femoral neck BMD (0.83 versus 0.81g/cm2, P<0.01), higher lumbar spine BMD (1.11 versus 1.06g/cm2, P<0.01), and lower risk of fracture than non-users (OR 0.68, 95% CI: 0.53-0.87). The associations between BB use and fracture risk were independent of age, BMD, and clinical risk factors. Subgroup analysis suggested that the association was mainly found in selective BB, not in non-selective BB. Conclusion: Beta-blockers use, particularly selective BB, was associated with reduced fracture risk in both men and women, and the association was independent of BMD. © 2010 Elsevier Inc.	en_US
dc.relation.ispartof	Bone	en_US
dc.relation.isbasedon	10.1016/j.bone.2010.10.170	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.subject.mesh	Femur Neck	en_US
dc.subject.mesh	Lumbar Vertebrae	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Osteoporosis	en_US
dc.subject.mesh	Adrenergic beta-Antagonists	en_US
dc.subject.mesh	Multivariate Analysis	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Fractures, Bone	en_US
dc.title	Association between beta-blocker use and fracture risk: The Dubbo Osteoporosis Epidemiology Study	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	48	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	09 Engineering	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	48	en_US

Abstract:

Introduction: In animal model, mice treated with beta-blockers (BB) had increased bone mass. In humans, high bone mass is associated with reduce fracture risk. The present study sought to test the hypothesis that BB use is associated with reduced fracture risk. Materials and methods: Data from 3488 participants (1285 men) aged 50. years and above in the Dubbo Osteoporosis Epidemiology Study (DOES) were analyzed. Baseline characteristics of participants were obtained at the initial visit which had taken place between 1989 and 1993. Bone mineral density (BMD) at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry (GE-LUNAR Corp, Madison, WI). Two hundred and sixty two (20%) men and 411 (19%) women had been on BB, as ascertained by direct interview and verification with medication history. The incidence of fragility fractures was ascertained during the follow-up period (1989-2008). Results: In men, BB use was associated with higher BMD at the femoral neck (0.96 versus 0.92g/cm2, P<0.01), higher lumbar spine (1.32 versus 1.25g/cm2, P<0.01), and lower fracture risk than those not on BB (odds ratio [OR]: 0.49; 95% CI: 0.32-0.75). In women, BB users also had higher femoral neck BMD (0.83 versus 0.81g/cm2, P<0.01), higher lumbar spine BMD (1.11 versus 1.06g/cm2, P<0.01), and lower risk of fracture than non-users (OR 0.68, 95% CI: 0.53-0.87). The associations between BB use and fracture risk were independent of age, BMD, and clinical risk factors. Subgroup analysis suggested that the association was mainly found in selective BB, not in non-selective BB. Conclusion: Beta-blockers use, particularly selective BB, was associated with reduced fracture risk in both men and women, and the association was independent of BMD. © 2010 Elsevier Inc.

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http://hdl.handle.net/10453/28732