Association between vitamin D insufficiency and tuberculosis in a vietnamese population

Ho-Pham, LT; Nguyen, ND; Nguyen, TT; Nguyen, DH; Bui, PK; Nguyen, VN; Nguyen, TV

Association between vitamin D insufficiency and tuberculosis in a vietnamese population

Ho-Pham, LT Nguyen, ND Nguyen, TT Nguyen, DH Bui, PK Nguyen, VN Nguyen, TV

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Publication Type:: Journal Article
Citation:: BMC Infectious Diseases, 2010, 10
Issue Date:: 2010-10-25

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Field	Value	Language
dc.contributor.author	Ho-Pham, LT	en_US
dc.contributor.author	Nguyen, ND	en_US
dc.contributor.author	Nguyen, TT	en_US
dc.contributor.author	Nguyen, DH	en_US
dc.contributor.author	Bui, PK	en_US
dc.contributor.author	Nguyen, VN	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.date.available	2010-10-25	en_US
dc.date.issued	2010-10-25	en_US
dc.identifier.citation	BMC Infectious Diseases, 2010, 10	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28734
dc.description.abstract	Background: Recent in vitro evidence suggests a link between vitamin D status and the risk of tuberculosis (TB). This study sought to examine the association between vitamin D status, parathyroid hormone (PTH) and the risk of TB in a Vietnamese population.Methods: The study was designed as a matched case-control study, which involved 166 TB patients (113 men and 53 women), who were age-and-sex matched with 219 controls (113 men and 106 women). The average age of men and women was 49 and 50, respectively. TB was diagnosed by the presence of acid-fast bacilli on smears from sputum, and the isolation of M. tuberculosis. All patients were hospitalized for treatment in a TB specialist hospital. Controls were randomly drawn from the general community within the Ho Chi Minh, Vietnam. 25-hydroxyvitamin D [25(OH)D] and PTH was measured prior to treatment by an electrochemiluminescence immunoassay (ECLIA) on a Roche Elecsys. A serum level of 25(OH)D below 30 ng/mL was deemed to be vitamin D insufficient.Results: The prevalence of vitamin D insufficiency was 35.4% in men with TB and 19.5% in controls (P = 0.01). In women, there were no significant differences in serum 25(OH)D and serum PTH levels between TB patients and controls. The prevalence of vitamin D insufficiency in women with TB (45.3%) was not significantly different from those without TB (47.6%; P = 0.91). However, in both genders, serum calcium levels in TB patients were significantly lower than in non-TB individuals. Smoking (odds ratio [OR] 1.25; 95% confidence interval [CI] 1.10 - 14.7), reduced 25(OH)D (OR per standard deviation [SD]: 1.14; 95% CI 1.07 - 10.7) and increased PTH (OR per SD 1.13; 95% CI 1.05 - 10.4) were independently associated with increased risk of TB in men.Conclusion: These results suggest that vitamin D insufficiency was a risk factor for tuberculosis in men, but not in women. However, it remains to be established whether the association is a causal relationship. © 2010 Ho-Pham et al; licensee BioMed Central Ltd.	en_US
dc.relation.ispartof	BMC Infectious Diseases	en_US
dc.relation.isbasedon	10.1186/1471-2334-10-306	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Sputum	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Mycobacterium tuberculosis	en_US
dc.subject.mesh	Tuberculosis	en_US
dc.subject.mesh	Vitamin D Deficiency	en_US
dc.subject.mesh	Parathyroid Hormone	en_US
dc.subject.mesh	Microscopy	en_US
dc.subject.mesh	Immunoassay	en_US
dc.subject.mesh	Clinical Laboratory Techniques	en_US
dc.subject.mesh	Staining and Labeling	en_US
dc.subject.mesh	Case-Control Studies	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Vietnam	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Association between vitamin D insufficiency and tuberculosis in a vietnamese population	en_US
dc.type	Journal Article
utslib.citation.volume	10	en_US
utslib.for	1108 Medical Microbiology	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	0605 Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	10	en_US

Abstract:

Background: Recent in vitro evidence suggests a link between vitamin D status and the risk of tuberculosis (TB). This study sought to examine the association between vitamin D status, parathyroid hormone (PTH) and the risk of TB in a Vietnamese population.Methods: The study was designed as a matched case-control study, which involved 166 TB patients (113 men and 53 women), who were age-and-sex matched with 219 controls (113 men and 106 women). The average age of men and women was 49 and 50, respectively. TB was diagnosed by the presence of acid-fast bacilli on smears from sputum, and the isolation of M. tuberculosis. All patients were hospitalized for treatment in a TB specialist hospital. Controls were randomly drawn from the general community within the Ho Chi Minh, Vietnam. 25-hydroxyvitamin D [25(OH)D] and PTH was measured prior to treatment by an electrochemiluminescence immunoassay (ECLIA) on a Roche Elecsys. A serum level of 25(OH)D below 30 ng/mL was deemed to be vitamin D insufficient.Results: The prevalence of vitamin D insufficiency was 35.4% in men with TB and 19.5% in controls (P = 0.01). In women, there were no significant differences in serum 25(OH)D and serum PTH levels between TB patients and controls. The prevalence of vitamin D insufficiency in women with TB (45.3%) was not significantly different from those without TB (47.6%; P = 0.91). However, in both genders, serum calcium levels in TB patients were significantly lower than in non-TB individuals. Smoking (odds ratio [OR] 1.25; 95% confidence interval [CI] 1.10 - 14.7), reduced 25(OH)D (OR per standard deviation [SD]: 1.14; 95% CI 1.07 - 10.7) and increased PTH (OR per SD 1.13; 95% CI 1.05 - 10.4) were independently associated with increased risk of TB in men.Conclusion: These results suggest that vitamin D insufficiency was a risk factor for tuberculosis in men, but not in women. However, it remains to be established whether the association is a causal relationship. © 2010 Ho-Pham et al; licensee BioMed Central Ltd.

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