Prevalence and risk factors of radiographic vertebral fracture in postmenopausal Vietnamese women

Ho-Pham, LT; Nguyen, ND; Vu, BQ; Pham, HN; Nguyen, TV

Prevalence and risk factors of radiographic vertebral fracture in postmenopausal Vietnamese women

Ho-Pham, LT Nguyen, ND Vu, BQ Pham, HN Nguyen, TV

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Publication Type:: Journal Article
Citation:: Bone, 2009, 45 (2), pp. 213 - 217
Issue Date:: 2009-08-01

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Field	Value	Language
dc.contributor.author	Ho-Pham, LT	en_US
dc.contributor.author	Nguyen, ND	en_US
dc.contributor.author	Vu, BQ	en_US
dc.contributor.author	Pham, HN	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.date.available	2009-04-10	en_US
dc.date.issued	2009-08-01	en_US
dc.identifier.citation	Bone, 2009, 45 (2), pp. 213 - 217	en_US
dc.identifier.issn	8756-3282	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28736
dc.description.abstract	Background: Vertebral fracture is associated with an increased risk of atraumatic fracture and mortality. The prevalence of vertebral fractures among postmenopausal Caucasian women has been reported to range between 15% and 35%. Because there is no estimate of the magnitude of the problem in Vietnam, we undertook this study to estimate the prevalence and risk factors of vertebral fracture in Vietnam. Methods: Radiographs were taken from 209 postmenopausal women aged between 50 and 85 years (average 62) who were randomly sampled from various districts in Ho Chi Minh City. The presence of vertebral fracture was assessed by the Genant's semi-quantitative method with two independent readers. Bone mineral density (BMD) at the lumbar spine (LS), femoral neck (FN) and whole body was measured by DXA (Hologic QDR4500). Anthropometric and clinical data were obtained by a standardized questionnaire. Results: Among the 209 women, 48 were found to have at least one radiographic vertebral fracture, which yielded a prevalence of 23% (95%CI: 18-29%). Although fracture occurred in all vertebrae, most (83%) occurred at the L1-L5. Most fractures occurred at one vertebra, and only 12% occurred at multiple vertebrae. The prevalence increased with age such that it reached 39% among those aged 70+ years. There was no significant association between vertebral fracture and back pain, fall history, and dietary calcium intake. In simple log-binomial regression analysis, higher risk of vertebral fracture was associated with advancing age (prevalence ratio [PR] per 10 years: 1.40; 1.16-2.05) and lower lumbar spine BMD (PR per SD: 1.51; 1.18-1.92). In multivariable analysis, the two factors remained independently associated with fracture risk, with the area under the receiver operating characteristic curve being 0.66. Conclusions: These data suggest that approximately one out of 4 postmenopausal women in Vietnam have a radiographic vertebral fracture, and this prevalence is as common as in Caucasian populations. The number of women needed to screen to identify one vertebral fracture is about 4 to 5, which seems to be cost-effective. © 2009 Elsevier Inc. All rights reserved.	en_US
dc.relation.ispartof	Bone	en_US
dc.relation.isbasedon	10.1016/j.bone.2009.04.199	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Spinal Fractures	en_US
dc.subject.mesh	Prevalence	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Demography	en_US
dc.subject.mesh	Postmenopause	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Asian Continental Ancestry Group	en_US
dc.subject.mesh	Vietnam	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Radiography	en_US
dc.title	Prevalence and risk factors of radiographic vertebral fracture in postmenopausal Vietnamese women	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	45	en_US
utslib.for	110306 Endocrinology	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	09 Engineering	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	45	en_US

Abstract:

Background: Vertebral fracture is associated with an increased risk of atraumatic fracture and mortality. The prevalence of vertebral fractures among postmenopausal Caucasian women has been reported to range between 15% and 35%. Because there is no estimate of the magnitude of the problem in Vietnam, we undertook this study to estimate the prevalence and risk factors of vertebral fracture in Vietnam. Methods: Radiographs were taken from 209 postmenopausal women aged between 50 and 85 years (average 62) who were randomly sampled from various districts in Ho Chi Minh City. The presence of vertebral fracture was assessed by the Genant's semi-quantitative method with two independent readers. Bone mineral density (BMD) at the lumbar spine (LS), femoral neck (FN) and whole body was measured by DXA (Hologic QDR4500). Anthropometric and clinical data were obtained by a standardized questionnaire. Results: Among the 209 women, 48 were found to have at least one radiographic vertebral fracture, which yielded a prevalence of 23% (95%CI: 18-29%). Although fracture occurred in all vertebrae, most (83%) occurred at the L1-L5. Most fractures occurred at one vertebra, and only 12% occurred at multiple vertebrae. The prevalence increased with age such that it reached 39% among those aged 70+ years. There was no significant association between vertebral fracture and back pain, fall history, and dietary calcium intake. In simple log-binomial regression analysis, higher risk of vertebral fracture was associated with advancing age (prevalence ratio [PR] per 10 years: 1.40; 1.16-2.05) and lower lumbar spine BMD (PR per SD: 1.51; 1.18-1.92). In multivariable analysis, the two factors remained independently associated with fracture risk, with the area under the receiver operating characteristic curve being 0.66. Conclusions: These data suggest that approximately one out of 4 postmenopausal women in Vietnam have a radiographic vertebral fracture, and this prevalence is as common as in Caucasian populations. The number of women needed to screen to identify one vertebral fracture is about 4 to 5, which seems to be cost-effective. © 2009 Elsevier Inc. All rights reserved.

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http://hdl.handle.net/10453/28736