Serum level of under-carboxylated osteocalcin and bone mineral density in early menopausal Norwegian women

Emaus, N; Nguyen, ND; Almaas, B; Berntsen, GK; Center, JR; Christensen, M; Gjesdal, CG; Grimsgaard, AS; Nguyen, TV; Salomonsen, L; Eisman, JA; Fønnebø, VM

Serum level of under-carboxylated osteocalcin and bone mineral density in early menopausal Norwegian women

Emaus, N Nguyen, ND Almaas, B Berntsen, GK Center, JR Christensen, M Gjesdal, CG Grimsgaard, AS Nguyen, TV

Salomonsen, L Eisman, JA Fønnebø, VM

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Publication Type:: Journal Article
Citation:: European Journal of Nutrition, 2013, 52 (1), pp. 49 - 55
Issue Date:: 2013-02-01

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Field	Value	Language
dc.contributor.author	Emaus, N	en_US
dc.contributor.author	Nguyen, ND	en_US
dc.contributor.author	Almaas, B	en_US
dc.contributor.author	Berntsen, GK	en_US
dc.contributor.author	Center, JR	en_US
dc.contributor.author	Christensen, M	en_US
dc.contributor.author	Gjesdal, CG	en_US
dc.contributor.author	Grimsgaard, AS	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.contributor.author	Salomonsen, L	en_US
dc.contributor.author	Eisman, JA	en_US
dc.contributor.author	Fønnebø, VM	en_US
dc.date.available	2011-11-17	en_US
dc.date.issued	2013-02-01	en_US
dc.identifier.citation	European Journal of Nutrition, 2013, 52 (1), pp. 49 - 55	en_US
dc.identifier.issn	1436-6207	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28779
dc.description.abstract	Purpose: Serum level of under-carboxylated osteocalcin (ucOC) is considered a sensitive measure of vitamin K status, and ucOC levels are associated with bone mineral density (BMD) and fracture risk in elderly persons. The aim of this study was to assess the relationship between ucOC and BMD in early menopausal women. Methods: The data reported here come from the enrolment in a double-blinded placebo-controlled randomized trial comprising 334 healthy Norwegian women between 50 and 60 years, 1-5 years after menopause, not using warfarin or medication known to affect bone metabolism. Total hip, femoral neck, lumbar spine, and total body BMD and serum level of ucOC and total osteocalcin were measured, and information of lifestyle was collected through questionnaires. The association between ucOC and BMD at all measurement sites was assessed by multiple regression analyses adjusting for possible confounding variables. Results: The absolute serum level of ucOC was significantly and negatively associated with BMD at all measurements sites, both in univariate analyses (p < 0.01) and in multivariate analyses adjusting for years since menopause, smoking status and weight (p < 0.01). However, serum ucOC, expressed as percentage of the total osteocalcin level, was not associated with BMD at any site. Conclusions: Achievement of adequate vitamin K nutritional intake is important, but ucOC expressed as percentage of total osteocalcin levels as reflection of vitamin K status does not seem to play a central role in determining BMD levels in early menopausal women. © 2011 Springer-Verlag.	en_US
dc.relation.ispartof	European Journal of Nutrition	en_US
dc.relation.isbasedon	10.1007/s00394-011-0285-1	en_US
dc.subject.classification	Nutrition & Dietetics	en_US
dc.subject.mesh	Femur Neck	en_US
dc.subject.mesh	Lumbar Vertebrae	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Body Weight	en_US
dc.subject.mesh	Vitamin K	en_US
dc.subject.mesh	Osteocalcin	en_US
dc.subject.mesh	Body Mass Index	en_US
dc.subject.mesh	Body Height	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Double-Blind Method	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Menopause	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Norway	en_US
dc.subject.mesh	Regression Analysis	en_US
dc.subject.mesh	Surveys and Questionnaires	en_US
dc.title	Serum level of under-carboxylated osteocalcin and bone mineral density in early menopausal Norwegian women	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	52	en_US
utslib.for	1111 Nutrition and Dietetics	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	52	en_US

Abstract:

Purpose: Serum level of under-carboxylated osteocalcin (ucOC) is considered a sensitive measure of vitamin K status, and ucOC levels are associated with bone mineral density (BMD) and fracture risk in elderly persons. The aim of this study was to assess the relationship between ucOC and BMD in early menopausal women. Methods: The data reported here come from the enrolment in a double-blinded placebo-controlled randomized trial comprising 334 healthy Norwegian women between 50 and 60 years, 1-5 years after menopause, not using warfarin or medication known to affect bone metabolism. Total hip, femoral neck, lumbar spine, and total body BMD and serum level of ucOC and total osteocalcin were measured, and information of lifestyle was collected through questionnaires. The association between ucOC and BMD at all measurement sites was assessed by multiple regression analyses adjusting for possible confounding variables. Results: The absolute serum level of ucOC was significantly and negatively associated with BMD at all measurements sites, both in univariate analyses (p < 0.01) and in multivariate analyses adjusting for years since menopause, smoking status and weight (p < 0.01). However, serum ucOC, expressed as percentage of the total osteocalcin level, was not associated with BMD at any site. Conclusions: Achievement of adequate vitamin K nutritional intake is important, but ucOC expressed as percentage of total osteocalcin levels as reflection of vitamin K status does not seem to play a central role in determining BMD levels in early menopausal women. © 2011 Springer-Verlag.

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http://hdl.handle.net/10453/28779