Endogenous sex hormones and incident fracture risk in older men: The Dubbo osteoporosis epidemiology study

Meier, C; Nguyen, TV; Handelsman, DJ; Schindler, C; Kushnir, MM; Rockwood, AL; Meikle, AW; Center, JR; Eisman, JA; Seibel, MJ

Endogenous sex hormones and incident fracture risk in older men: The Dubbo osteoporosis epidemiology study

Meier, C Nguyen, TV

Handelsman, DJ Schindler, C Kushnir, MM Rockwood, AL Meikle, AW Center, JR Eisman, JA Seibel, MJ

Permalink

Publication Type:: Journal Article
Citation:: Archives of Internal Medicine, 2008, 168 (1), pp. 47 - 54
Issue Date:: 2008-01-14

Closed Access

	Filename	Description	Size
	2013005883OK.pdf		126.88 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Meier, C	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.contributor.author	Handelsman, DJ	en_US
dc.contributor.author	Schindler, C	en_US
dc.contributor.author	Kushnir, MM	en_US
dc.contributor.author	Rockwood, AL	en_US
dc.contributor.author	Meikle, AW	en_US
dc.contributor.author	Center, JR	en_US
dc.contributor.author	Eisman, JA	en_US
dc.contributor.author	Seibel, MJ	en_US
dc.date.issued	2008-01-14	en_US
dc.identifier.citation	Archives of Internal Medicine, 2008, 168 (1), pp. 47 - 54	en_US
dc.identifier.issn	0003-9926	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28798
dc.description.abstract	Background: Data on the influence of gonadal hormones on incident fracture risk in elderly men are limited. We prospectively examined the relationship between serum levels of testosterone and estradiol and future fracture risk in community-dwelling men. Methods: A total of 609 men older than 60 years had been observed between January 1989 and December 2005, with the median duration being 5.8 years (up to 13 years). Clinical risk factors, including bone mineral density and lifestyle factors, were assessed at baseline. Serum testosterone and estradiol levels were measured by tandem mass spectrometry. The incidence of a low-trauma fracture was ascertained during follow-up. Results: During follow-up, 113 men had at least 1 low-trauma fracture. The risk of fracture was significantly increased in men with reduced testosterone levels (hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.09-1.62). After adjustment for sex hormone-binding globulin, serum testosterone (HR, 1.48; 95% CI, 1.22-1.78) and serum estradiol (HR, 1.21; 95% CI, 1.00-1.47) levels were associated with overall fracture risk. After further adjustment for major risk factors of fractures (age, weight or bone mineral density, fracture history, smoking status, calcium intake, and sex hormone-binding globulin), lower testosterone was still associated with increased risk of fracture, particularly with hip (HR, 1.88; 95% CI, 1.24-2.82) and nonvertebral (HR, 1.32; 95% CI, 1.03-1.68) fractures. Conclusion: In community-dwelling men older than 60 years, serum testosterone is independently associated with the risk of osteoporotic fracture and its measurement may provide additional clinical information for the assessment of fracture risk in elderly men. ©2008 American Medical Association. All rights reserved.	en_US
dc.relation.ispartof	Archives of Internal Medicine	en_US
dc.relation.isbasedon	10.1001/archinternmed.2007.2	en_US
dc.subject.classification	General & Internal Medicine	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Osteoporosis	en_US
dc.subject.mesh	Testosterone	en_US
dc.subject.mesh	Estradiol	en_US
dc.subject.mesh	Incidence	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Follow-Up Studies	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Life Style	en_US
dc.subject.mesh	Bone Density	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Fractures, Bone	en_US
dc.title	Endogenous sex hormones and incident fracture risk in older men: The Dubbo osteoporosis epidemiology study	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	168	en_US
utslib.for	110306 Endocrinology	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	168	en_US

Abstract:

Background: Data on the influence of gonadal hormones on incident fracture risk in elderly men are limited. We prospectively examined the relationship between serum levels of testosterone and estradiol and future fracture risk in community-dwelling men. Methods: A total of 609 men older than 60 years had been observed between January 1989 and December 2005, with the median duration being 5.8 years (up to 13 years). Clinical risk factors, including bone mineral density and lifestyle factors, were assessed at baseline. Serum testosterone and estradiol levels were measured by tandem mass spectrometry. The incidence of a low-trauma fracture was ascertained during follow-up. Results: During follow-up, 113 men had at least 1 low-trauma fracture. The risk of fracture was significantly increased in men with reduced testosterone levels (hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.09-1.62). After adjustment for sex hormone-binding globulin, serum testosterone (HR, 1.48; 95% CI, 1.22-1.78) and serum estradiol (HR, 1.21; 95% CI, 1.00-1.47) levels were associated with overall fracture risk. After further adjustment for major risk factors of fractures (age, weight or bone mineral density, fracture history, smoking status, calcium intake, and sex hormone-binding globulin), lower testosterone was still associated with increased risk of fracture, particularly with hip (HR, 1.88; 95% CI, 1.24-2.82) and nonvertebral (HR, 1.32; 95% CI, 1.03-1.68) fractures. Conclusion: In community-dwelling men older than 60 years, serum testosterone is independently associated with the risk of osteoporotic fracture and its measurement may provide additional clinical information for the assessment of fracture risk in elderly men. ©2008 American Medical Association. All rights reserved.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/28798