Association Between Beta-Blockers And Fracture Risk: A Bayesian Meta-Analysis

Elsevier Science Inc
Publication Type:
Journal Article
Bone, 2012, 51 (5), pp. 969 - 974
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Background: The association between beta-blockers (BB) and fracture risk is controversial, due largely to conflicting findings from previous studies. The present study sought to evaluate the effect of BB on fracture risk by using a Bayesian meta-analysis approach. Methods and results: We systematically retrieved 13 observational studies on the association between BB use and fracture risk. This meta-analysis involved more than 907.000 men and women with mean/median age of individual studies ranging from 43 to 81 years. We used a hierarchical Bayesian random effects model to synthesize the results. BB use was associated with an average 17% reduction in the risk of any fracture (risk ratio [RR] 0.83: 95% credible interval [Crl]: 0.71-0.93), hip fracture (RR 0.83: 95% Crl: 0.70-0.92) and vertebral fracture (RR 0.81:95% Crl: 0.61-0.99). The probability that BB use reduces fracture risk by at least 10% was 0.91. Conclusions: Beta-blockers are associated with reduced risk of fracture in older adults, but the effect size is likely to be modest. (C) 2012 Elsevier Inc. All rights reserved.
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