Patients with thrombolysed stroke in Vietnam have an excellent outcome: Results from the Vietnam Thrombolysis Registry

Nguyen, TH; Truong, ALT; Ngo, MB; Bui, CTQ; Dinh, QV; Doan, TC; Nguyen, LTK; Phan, TC; Phan, MV; Nguyen, TV; Le, TV

Patients with thrombolysed stroke in Vietnam have an excellent outcome: Results from the Vietnam Thrombolysis Registry

Nguyen, TH Truong, ALT Ngo, MB Bui, CTQ Dinh, QV Doan, TC Nguyen, LTK Phan, TC Phan, MV Nguyen, TV

Le, TV

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Publication Type:: Journal Article
Citation:: European Journal of Neurology, 2010, 17 (9), pp. 1188 - 1192
Issue Date:: 2010-09-01

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Field	Value	Language
dc.contributor.author	Nguyen, TH	en_US
dc.contributor.author	Truong, ALT	en_US
dc.contributor.author	Ngo, MB	en_US
dc.contributor.author	Bui, CTQ	en_US
dc.contributor.author	Dinh, QV	en_US
dc.contributor.author	Doan, TC	en_US
dc.contributor.author	Nguyen, LTK	en_US
dc.contributor.author	Phan, TC	en_US
dc.contributor.author	Phan, MV	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.contributor.author	Le, TV	en_US
dc.date.issued	2010-09-01	en_US
dc.identifier.citation	European Journal of Neurology, 2010, 17 (9), pp. 1188 - 1192	en_US
dc.identifier.issn	1351-5101	en_US
dc.identifier.uri	http://hdl.handle.net/10453/28803
dc.description.abstract	Background and purpose: We present the early experience in thrombolysis in three major centers of Ho Chi Minh city, namely 115 People Hospital, Gia Dinh Hospital, and An Binh Hospital. Methods: A prospective study of consecutive patients treated with intravenous tPA with a treatment protocol similar to that of the National Institute of Neurological Disorders and Stroke (NINDS) trial. National Institutes of Health Stroke Scale (NIHSS) scores on admission and Modified Rankin Scale (MRS) scores at 3 months were measured for all patients. Intracranial and systemic hemorrhagic complications were recorded. Result: A total of 121 of 6171 (2%) patients with acute IS received thrombolysis over 3 years. Mean age was 57 years (range 18-78) and initial median NIHSS score was 12 (range 5-23). The mean delay between symptom onset and treatment was 143 min (range 50-210). Seventy-three (60.3%) patients received the standard dose with the remaining 48 patients (36.9%) treated with a lower dose, a mean calculated dose of 0.62 mgkg (range, 0.6-0.86 mgkg). Over half (56.3%) of the patients receiving low dose achieved functional independence (mRS score 0-1) at 3 months compared with 34.2% in the standard-dose group (P = 0.01). The 3-month mortality rate was also higher in the standard-dose group (2.1% vs. 12.5% with standard-dose tPA; P = 0.04). Symptomatic intracranial hemorrhage was noted in four patients of standard-dose group and one patient of low-dose group (P = 0.36). Conclusion: Intravenous thrombolysis, particularly in a lower dose, is safe and feasible in the treatment of acute IS in our selected Vietnamese population. © 2010 EFNS.	en_US
dc.relation.ispartof	European Journal of Neurology	en_US
dc.relation.isbasedon	10.1111/j.1468-1331.2010.02995.x	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Intracranial Thrombosis	en_US
dc.subject.mesh	Fibrinolytic Agents	en_US
dc.subject.mesh	Treatment Outcome	en_US
dc.subject.mesh	Thrombolytic Therapy	en_US
dc.subject.mesh	Registries	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Dose-Response Relationship, Drug	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Emergency Medical Services	en_US
dc.subject.mesh	Outcome Assessment (Health Care)	en_US
dc.subject.mesh	Vietnam	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Stroke	en_US
dc.subject.mesh	Young Adult	en_US
dc.subject.mesh	Outcome Assessment, Health Care	en_US
dc.title	Patients with thrombolysed stroke in Vietnam have an excellent outcome: Results from the Vietnam Thrombolysis Registry	en_US
dc.type	Journal Article
utslib.citation.volume	9	en_US
utslib.citation.volume	17	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1109 Neurosciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	9	en_US
pubs.publication-status	Published	en_US
pubs.volume	17	en_US

Abstract:

Background and purpose: We present the early experience in thrombolysis in three major centers of Ho Chi Minh city, namely 115 People Hospital, Gia Dinh Hospital, and An Binh Hospital. Methods: A prospective study of consecutive patients treated with intravenous tPA with a treatment protocol similar to that of the National Institute of Neurological Disorders and Stroke (NINDS) trial. National Institutes of Health Stroke Scale (NIHSS) scores on admission and Modified Rankin Scale (MRS) scores at 3 months were measured for all patients. Intracranial and systemic hemorrhagic complications were recorded. Result: A total of 121 of 6171 (2%) patients with acute IS received thrombolysis over 3 years. Mean age was 57 years (range 18-78) and initial median NIHSS score was 12 (range 5-23). The mean delay between symptom onset and treatment was 143 min (range 50-210). Seventy-three (60.3%) patients received the standard dose with the remaining 48 patients (36.9%) treated with a lower dose, a mean calculated dose of 0.62 mgkg (range, 0.6-0.86 mgkg). Over half (56.3%) of the patients receiving low dose achieved functional independence (mRS score 0-1) at 3 months compared with 34.2% in the standard-dose group (P = 0.01). The 3-month mortality rate was also higher in the standard-dose group (2.1% vs. 12.5% with standard-dose tPA; P = 0.04). Symptomatic intracranial hemorrhage was noted in four patients of standard-dose group and one patient of low-dose group (P = 0.36). Conclusion: Intravenous thrombolysis, particularly in a lower dose, is safe and feasible in the treatment of acute IS in our selected Vietnamese population. © 2010 EFNS.

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http://hdl.handle.net/10453/28803