Desenvolvimento e caracterizacao de nanoparticulas lipidicas destinadas a aplicacao topica de dapsona.

Santos, GS; Garrastazu Pereira, G; Bender, EA; Colome, LM; Guterres, SS; Carvalho, DC; Weissmuller, G

Desenvolvimento e caracterizacao de nanoparticulas lipidicas destinadas a aplicacao topica de dapsona.

Santos, GS Garrastazu Pereira, G Bender, EA Colome, LM Guterres, SS Carvalho, DC Weissmuller, G

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Publisher:: Sociedade Brazileira de Quimica
Publication Type:: Journal Article
Citation:: Quim. Nova, 2012, 35 pp. 1388 - 1394
Issue Date:: 2012-01

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Field	Value	Language
dc.contributor.author	Santos, GS	en_US
dc.contributor.author	Garrastazu Pereira, G	en_US
dc.contributor.author	Bender, EA	en_US
dc.contributor.author	Colome, LM	en_US
dc.contributor.author	Guterres, SS	en_US
dc.contributor.author	Carvalho, DC	en_US
dc.contributor.author	Weissmuller, G	en_US
dc.date.issued	2012-01	en_US
dc.identifier.citation	Quim. Nova, 2012, 35 pp. 1388 - 1394	en_US
dc.identifier.issn	0100-4042	en_US
dc.identifier.uri	http://hdl.handle.net/10453/29891
dc.description.abstract	DEVELOPMENT AND CHARACTERIZATION OF LIPID NANOPARTICLES FOR DAPSONE TOPICAL APPLICATION. In this work, theospheres (innovative lipid nanoparticles) were prepared by the high pressure homogenization technique using different surfactants for dapsone encapsulation. Mean particle size ranged from 105 to 153 nm and negative zeta potentials were obtained for all theosphere formulations. Atomic force microscopy images confirmed the spherical shape of theospheres. The HPLC method used to determine dapsone-loaded theospheres was selective, linear, exact and precise. The entrapment efficiency of dapsone was 91.4%. Theospheres provided controlled release of idebenone (52.7 ± 1.6%) in comparison to the free drug (103.1 ± 1.9%).	en_US
dc.language	Portuguese	en_US
dc.publisher	Sociedade Brazileira de Quimica	en_US
dc.relation.ispartof	Quim. Nova	en_US
dc.relation.isbasedon	10.1590/S0100-40422012000700019	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.title	Desenvolvimento e caracterizacao de nanoparticulas lipidicas destinadas a aplicacao topica de dapsona.	en_US
dc.type	Journal Article
utslib.citation.volume	35	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	03 Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.consider-herdc	false	en_US
pubs.volume	35	en_US

Abstract:

DEVELOPMENT AND CHARACTERIZATION OF LIPID NANOPARTICLES FOR DAPSONE TOPICAL APPLICATION. In this work, theospheres (innovative lipid nanoparticles) were prepared by the high pressure homogenization technique using different surfactants for dapsone encapsulation. Mean particle size ranged from 105 to 153 nm and negative zeta potentials were obtained for all theosphere formulations. Atomic force microscopy images confirmed the spherical shape of theospheres. The HPLC method used to determine dapsone-loaded theospheres was selective, linear, exact and precise. The entrapment efficiency of dapsone was 91.4%. Theospheres provided controlled release of idebenone (52.7 ± 1.6%) in comparison to the free drug (103.1 ± 1.9%).

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http://hdl.handle.net/10453/29891