Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation

Johnston, M; Hutvagner, G

Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation

Johnston, M Hutvagner, G

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Publication Type:: Journal Article
Citation:: Silence, 2011, 2 (1)
Issue Date:: 2011-09-26

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Field	Value	Language
dc.contributor.author	Johnston, M	en_US
dc.contributor.author	Hutvagner, G https://orcid.org/0000-0002-7231-9446	en_US
dc.date.available	2011-09-26	en_US
dc.date.issued	2011-09-26	en_US
dc.identifier.citation	Silence, 2011, 2 (1)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/31123
dc.description.abstract	Shortly after their discovery, repertoires of miRNA were identified, together with proteins involved in their biogenesis and action. It is now obvious that miRNA-mediated gene regulation itself is regulated at multiple levels. Identifying the regulatory mechanisms that underpin small RNA homeostasis by modulation of their biogenesis and action has become a key issue, which can be partly resolved by identifying mediators of Argonautes turnover. An emerging theme in the control of Argonaute stability and activity is through posttranslational modifications, which are the focus of this review. © 2011 Johnston and Hutvagner; licensee BioMed Central Ltd.	en_US
dc.relation.ispartof	Silence	en_US
dc.relation.isbasedon	10.1186/1758-907X-2-5	en_US
dc.title	Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	2	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	0604 Genetics	en_US
utslib.for	0607 Plant Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	2	en_US

Abstract:

Shortly after their discovery, repertoires of miRNA were identified, together with proteins involved in their biogenesis and action. It is now obvious that miRNA-mediated gene regulation itself is regulated at multiple levels. Identifying the regulatory mechanisms that underpin small RNA homeostasis by modulation of their biogenesis and action has become a key issue, which can be partly resolved by identifying mediators of Argonautes turnover. An emerging theme in the control of Argonaute stability and activity is through posttranslational modifications, which are the focus of this review. © 2011 Johnston and Hutvagner; licensee BioMed Central Ltd.

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http://hdl.handle.net/10453/31123