Synthetic glycopolypeptides as potential inhibitory agents for dendritic cells and HIV-1 trafficking.

Publication Type:
Journal Article
Macromol Rapid Commun, 2013, 34 (19), pp. 1542 - 1546
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Multivalent binding is a key for many critical biological processes and unique recognition and specificity in binding enables many of different glycans and proteins to work in a great harmony within the human body. In this study, the binding kinetics of synthetic glycopolypeptides to the dendritic cell lectin DC-SIGN and their inhibition potential for DC-SIGN interactions with the gp120 envelope glycoprotein of HIV-1 (gp120) are investigated.
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