Transcriptional regulation of cytokine function in airway smooth muscle cells

Publisher:
Elsevier Ltd.
Publication Type:
Journal Article
Citation:
Pulmonary Pharmacology and Therapeutics, 2009, 22 (5), pp. 436 - 445
Issue Date:
2009-01
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Despite numerous studies of the cellular effects of cytokines on cultured ASM, few have identified intracellular signaling pathways by which cytokines modulate or induce these cellular responses. In this review we provide an overview of the transcriptional mechanisms as well as intracellular signaling pathways regulating cytokine functions in ASM cells. The recent discovery of toll-like receptors in ASM cells represents a significant development in our understanding of the immuno-modulatory capabilities of ASM cells. Thus, we also review emerging evidence of the inflammatory response to toll-like receptor activation in ASM cells.
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