Transcriptional regulation of cytokine function in airway smooth muscle cells

Elsevier Ltd.
Publication Type:
Journal Article
Pulmonary Pharmacology and Therapeutics, 2009, 22 (5), pp. 436 - 445
Issue Date:
Full metadata record
Files in This Item:
Filename Description Size
2011006418OK.pdfPublished Version522.43 kB
Adobe PDF
Despite numerous studies of the cellular effects of cytokines on cultured ASM, few have identified intracellular signaling pathways by which cytokines modulate or induce these cellular responses. In this review we provide an overview of the transcriptional mechanisms as well as intracellular signaling pathways regulating cytokine functions in ASM cells. The recent discovery of toll-like receptors in ASM cells represents a significant development in our understanding of the immuno-modulatory capabilities of ASM cells. Thus, we also review emerging evidence of the inflammatory response to toll-like receptor activation in ASM cells.
Please use this identifier to cite or link to this item: