Limited relationships between two-year changes in sulcal morphology and other common neuroimaging indices in the elderly

Liu, T; Sachdev, PS; Lipnicki, DM; Jiang, J; Geng, G; Zhu, W; Reppermund, S; Tao, D; Trollor, JN; Brodaty, H; Wen, W

Limited relationships between two-year changes in sulcal morphology and other common neuroimaging indices in the elderly

Liu, T

Sachdev, PS Lipnicki, DM Jiang, J Geng, G Zhu, W Reppermund, S Tao, D

Trollor, JN Brodaty, H Wen, W

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Publication Type:: Journal Article
Citation:: NeuroImage, 2013, 83 pp. 12 - 17
Issue Date:: 2013-12-01

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Field	Value	Language
dc.contributor.author	Liu, T https://orcid.org/0000-0002-7783-3073	en_US
dc.contributor.author	Sachdev, PS	en_US
dc.contributor.author	Lipnicki, DM	en_US
dc.contributor.author	Jiang, J	en_US
dc.contributor.author	Geng, G	en_US
dc.contributor.author	Zhu, W	en_US
dc.contributor.author	Reppermund, S	en_US
dc.contributor.author	Tao, D https://orcid.org/0000-0001-7225-5449	en_US
dc.contributor.author	Trollor, JN	en_US
dc.contributor.author	Brodaty, H	en_US
dc.contributor.author	Wen, W	en_US
dc.date.available	2013-06-14	en_US
dc.date.issued	2013-12-01	en_US
dc.identifier.citation	NeuroImage, 2013, 83 pp. 12 - 17	en_US
dc.identifier.issn	1053-8119	en_US
dc.identifier.uri	http://hdl.handle.net/10453/32170
dc.description.abstract	Measuring the geometry or morphology of sulcal folds has recently become an important approach to investigating neuroanatomy. However, relationships between cortical sulci and other brain structures are poorly understood. The present study investigates how age-related changes in sulcal width are associated with age-related changes in traditional indices of brain structure such as cortical thickness, and cortical gray matter (GM), white matter (WM), subcortical, and white matter hyperintensity (WMH) volumes. These indices and sulcal width were measured at baseline and at two-year follow up in 185 community-dwelling individuals (91 men) aged 70-89. years. There were significant increases in sulcal width and WMH volume, and significant decreases in all other indices between baseline and follow-up. Sulcal widening was associated with decreases in cortical GM, subcortical and WM volumes. A further association between sulcal width and cortical thickness became non-significant when cortical GM volume was controlled for. Our findings give insights into the mechanisms responsible for cortical sulcal morphology. The relationships between sulcal morphology and other common measures suggest that it could be a more comprehensive measure for clinical classifications than traditional neuroimaging metrics, such as cortical thickness. © 2013 Elsevier Inc.	en_US
dc.relation.ispartof	NeuroImage	en_US
dc.relation.isbasedon	10.1016/j.neuroimage.2013.06.058	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Cerebral Cortex	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Atrophy	en_US
dc.subject.mesh	Magnetic Resonance Imaging	en_US
dc.subject.mesh	Organ Size	en_US
dc.subject.mesh	Sensitivity and Specificity	en_US
dc.subject.mesh	Longitudinal Studies	en_US
dc.subject.mesh	Reproducibility of Results	en_US
dc.subject.mesh	Aging	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Neuroimaging	en_US
dc.subject.mesh	Anatomic Landmarks	en_US
dc.subject.mesh	White Matter	en_US
dc.subject.mesh	Gray Matter	en_US
dc.title	Limited relationships between two-year changes in sulcal morphology and other common neuroimaging indices in the elderly	en_US
dc.type	Journal Article
utslib.citation.volume	83	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	83	en_US

Abstract:

Measuring the geometry or morphology of sulcal folds has recently become an important approach to investigating neuroanatomy. However, relationships between cortical sulci and other brain structures are poorly understood. The present study investigates how age-related changes in sulcal width are associated with age-related changes in traditional indices of brain structure such as cortical thickness, and cortical gray matter (GM), white matter (WM), subcortical, and white matter hyperintensity (WMH) volumes. These indices and sulcal width were measured at baseline and at two-year follow up in 185 community-dwelling individuals (91 men) aged 70-89. years. There were significant increases in sulcal width and WMH volume, and significant decreases in all other indices between baseline and follow-up. Sulcal widening was associated with decreases in cortical GM, subcortical and WM volumes. A further association between sulcal width and cortical thickness became non-significant when cortical GM volume was controlled for. Our findings give insights into the mechanisms responsible for cortical sulcal morphology. The relationships between sulcal morphology and other common measures suggest that it could be a more comprehensive measure for clinical classifications than traditional neuroimaging metrics, such as cortical thickness. © 2013 Elsevier Inc.

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http://hdl.handle.net/10453/32170