Preparation and characterization of LA/PCL composite fibers containing beta tricalcium phosphate (β-TCP) particles

Park, CH; Kim, EK; Tijing, LD; Amarjargal, A; Pant, HR; Kim, CS; Shon, HK

Preparation and characterization of LA/PCL composite fibers containing beta tricalcium phosphate (β-TCP) particles

Park, CH Kim, EK Tijing, LD

Amarjargal, A Pant, HR Kim, CS Shon, HK

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Publication Type:: Journal Article
Citation:: Ceramics International, 2014, 40 (3), pp. 5049 - 5054
Issue Date:: 2014-04-01

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Field	Value	Language
dc.contributor.author	Park, CH	en_US
dc.contributor.author	Kim, EK	en_US
dc.contributor.author	Tijing, LD https://orcid.org/0000-0001-9398-6355	en_US
dc.contributor.author	Amarjargal, A	en_US
dc.contributor.author	Pant, HR	en_US
dc.contributor.author	Kim, CS	en_US
dc.contributor.author	Shon, HK https://orcid.org/0000-0002-3777-7169	en_US
dc.date.issued	2014-04-01	en_US
dc.identifier.citation	Ceramics International, 2014, 40 (3), pp. 5049 - 5054	en_US
dc.identifier.issn	0272-8842	en_US
dc.identifier.uri	http://hdl.handle.net/10453/34629
dc.description.abstract	Beta-TCP (β-TCP) particle-containing LA/PCL micro/nanofibers were fabricated via a one-step electrospinning process. The morphology and chemical structure of the composite nanofibers were characterized by FESEM, XRD, and FTIR. Rougher surfaces were observed for the LA/PCL micro/nanofibers containing β-TCP compared to the neat LA/PCL fibers, which could possibly provide extra sites for cell binding. XRD and FTIR confirmed the presence of β-TCP as being firmly deposited on the fibers. After an immersion in distilled water, we observed that the β-TCP-containing composite fibers were more degradable with many damaged and broken fibers compared to the LA/PCL fibers. MTT assay and immersion test showed better cell viability and proliferation, and improved mineralization ability compared to the LA/PCL only mat. Thus, the incorporation of β-TCP and the presence of LA in PCL micro/nanofibers could result to an improved biocompatibility and faster degradation of the composite fibers, which would possibly be useful for tissue scaffold application. © 2013 Elsevier Ltd and Techna Group S.r.l.	en_US
dc.relation.ispartof	Ceramics International	en_US
dc.relation.isbasedon	10.1016/j.ceramint.2013.10.016	en_US
dc.subject.classification	Materials	en_US
dc.title	Preparation and characterization of LA/PCL composite fibers containing beta tricalcium phosphate (β-TCP) particles	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	40	en_US
utslib.for	0904 Chemical Engineering	en_US
utslib.for	0912 Materials Engineering	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	09 Engineering	en_US
utslib.for	19 Studies in Creative Arts and Writing	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	open_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	40	en_US

Abstract:

Beta-TCP (β-TCP) particle-containing LA/PCL micro/nanofibers were fabricated via a one-step electrospinning process. The morphology and chemical structure of the composite nanofibers were characterized by FESEM, XRD, and FTIR. Rougher surfaces were observed for the LA/PCL micro/nanofibers containing β-TCP compared to the neat LA/PCL fibers, which could possibly provide extra sites for cell binding. XRD and FTIR confirmed the presence of β-TCP as being firmly deposited on the fibers. After an immersion in distilled water, we observed that the β-TCP-containing composite fibers were more degradable with many damaged and broken fibers compared to the LA/PCL fibers. MTT assay and immersion test showed better cell viability and proliferation, and improved mineralization ability compared to the LA/PCL only mat. Thus, the incorporation of β-TCP and the presence of LA in PCL micro/nanofibers could result to an improved biocompatibility and faster degradation of the composite fibers, which would possibly be useful for tissue scaffold application. © 2013 Elsevier Ltd and Techna Group S.r.l.

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http://hdl.handle.net/10453/34629