Circulating microRNAs: Potential biomarkers for common malignancies

Khoury, S; Tran, N

Circulating microRNAs: Potential biomarkers for common malignancies

Khoury, S

Tran, N

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Publication Type:: Journal Article
Citation:: Biomarkers in Medicine, 2015, 9 (2), pp. 131 - 151
Issue Date:: 2015-01-01

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Field	Value	Language
dc.contributor.author	Khoury, S https://orcid.org/0000-0001-5631-7478	en_US
dc.contributor.author	Tran, N https://orcid.org/0000-0001-7747-2530	en_US
dc.date.issued	2015-01-01	en_US
dc.identifier.citation	Biomarkers in Medicine, 2015, 9 (2), pp. 131 - 151	en_US
dc.identifier.issn	1752-0363	en_US
dc.identifier.uri	http://hdl.handle.net/10453/36267
dc.description.abstract	© 2014 Future Medicine Ltd. MicroRNAs (miRNAs) belong to a class of small noncoding RNAs (ncRNAs), which regulate gene expression at the post-transcriptional level. They are approximately 22 nucleotide sequences in length and have been predicted to control expression of up to 30-60% of all protein-coding genes in mammals. Considering this wide involvement in gene control, aberrant miRNA expression has a strong association with the presence and progression of a disease, hence generating much anticipation in using miRNAs as biomarkers for the diagnosis and prognosis of human cancers. The majority of these miRNAs are intracellular, but recently they have been discovered in bodily fluids. This review will provide an insight into these circulatory miRNA molecules and discuss their potential as cancer biomarkers.	en_US
dc.relation.ispartof	Biomarkers in Medicine	en_US
dc.relation.isbasedon	10.2217/BMM.14.102	en_US
dc.subject.classification	Oncology & Carcinogenesis	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Neoplasms	en_US
dc.subject.mesh	MicroRNAs	en_US
dc.subject.mesh	Prognosis	en_US
dc.subject.mesh	Sensitivity and Specificity	en_US
dc.subject.mesh	Reproducibility of Results	en_US
dc.subject.mesh	Reverse Transcriptase Polymerase Chain Reaction	en_US
dc.subject.mesh	Gene Expression Regulation, Neoplastic	en_US
dc.subject.mesh	Biomarkers, Tumor	en_US
dc.title	Circulating microRNAs: Potential biomarkers for common malignancies	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	9	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	1101 Medical Biochemistry and Metabolomics	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	9	en_US

Abstract:

© 2014 Future Medicine Ltd. MicroRNAs (miRNAs) belong to a class of small noncoding RNAs (ncRNAs), which regulate gene expression at the post-transcriptional level. They are approximately 22 nucleotide sequences in length and have been predicted to control expression of up to 30-60% of all protein-coding genes in mammals. Considering this wide involvement in gene control, aberrant miRNA expression has a strong association with the presence and progression of a disease, hence generating much anticipation in using miRNAs as biomarkers for the diagnosis and prognosis of human cancers. The majority of these miRNAs are intracellular, but recently they have been discovered in bodily fluids. This review will provide an insight into these circulatory miRNA molecules and discuss their potential as cancer biomarkers.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/36267