An EEG study of turning freeze in Parkinson's disease patients: The alteration of brain dynamic on the motor and visual cortex

Handojoseno, AMA; Gilat, M; Ly, QT; Chamtie, H; Shine, JM; Nguyen, TN; Tran, Y; Lewis, SJG; Nguyen, HT

An EEG study of turning freeze in Parkinson's disease patients: The alteration of brain dynamic on the motor and visual cortex

Handojoseno, AMA Gilat, M Ly, QT Chamtie, H Shine, JM Nguyen, TN

Tran, Y

Lewis, SJG Nguyen, HT

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Publication Type:: Conference Proceeding
Citation:: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2015, 2015-November pp. 6618 - 6621
Issue Date:: 2015-11-04

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Field	Value	Language
dc.contributor.author	Handojoseno, AMA	en_US
dc.contributor.author	Gilat, M	en_US
dc.contributor.author	Ly, QT	en_US
dc.contributor.author	Chamtie, H	en_US
dc.contributor.author	Shine, JM	en_US
dc.contributor.author	Nguyen, TN https://orcid.org/0000-0002-9958-9876	en_US
dc.contributor.author	Tran, Y https://orcid.org/0000-0002-1741-4205	en_US
dc.contributor.author	Lewis, SJG	en_US
dc.contributor.author	Nguyen, HT https://orcid.org/0000-0003-3373-8178	en_US
dc.date.available	2015-06-30	en_US
dc.date.issued	2015-11-04	en_US
dc.identifier.citation	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2015, 2015-November pp. 6618 - 6621	en_US
dc.identifier.isbn	9781424492718	en_US
dc.identifier.issn	1557-170X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/37093
dc.identifier.uri	http://hdl.handle.net/10453/37102
dc.identifier.uri	http://hdl.handle.net/10453/37712
dc.identifier.uri	http://hdl.handle.net/10453/37084
dc.identifier.uri	http://hdl.handle.net/10453/37092
dc.identifier.uri	http://hdl.handle.net/10453/37091
dc.identifier.uri	http://hdl.handle.net/10453/37101
dc.description.abstract	© 2015 IEEE. Freezing of gait is a very debilitating symptom affecting many patients with Parkinson's disease, leading to a reduced mobility and increased risk for falls. Turning is known to be the most provocative trigger for freezing of gait. However, the underlying brain dynamic changes associated with a turning freeze remain unknown. This study therefore used ambulatory EEG to investigate the brain dynamic changes associated with freezing of gait during turning. In addition, this study aimed to determine the most suitable EEG sensor location to detect freezing of gait during turning using our classification system. Data from four Parkinson's disease patients with freezing of gait was analysed using power spectral density and brain effective connectivity, comparing periods of successful turning with freezing of gait during turning. Results showed that freezing of gait during turning is associated with significant alterations in the high beta and theta power spectral densities across the occipital and parietal areas. Furthermore, brain effective connectivity showed that freezing during turning was associated with increased connectivity towards the visual area, which also had the highest accuracy to detect freezing episodes in the O1 regions by using power spectral density in our classification analyses. This is the first study to show cortical dynamic changes associated with freezing of gait during turning, providing valuable information to enhance the performance of future freezing of gait detection systems.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1062319
dc.relation.ispartof	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS	en_US
dc.relation.isbasedon	10.1109/EMBC.2015.7319910	en_US
dc.subject.mesh	Motor Cortex	en_US
dc.subject.mesh	Visual Cortex	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Parkinson Disease	en_US
dc.subject.mesh	Gait Disorders, Neurologic	en_US
dc.subject.mesh	Electroencephalography	en_US
dc.subject.mesh	Monitoring, Ambulatory	en_US
dc.title	An EEG study of turning freeze in Parkinson's disease patients: The alteration of brain dynamic on the motor and visual cortex	en_US
dc.type	Conference Proceeding
utslib.citation.volume	2015-November	en_US
utslib.for	090303 Biomedical Instrumentation	en_US
dc.location.activity	Milano, Italy
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	2015-November	en_US

Abstract:

© 2015 IEEE. Freezing of gait is a very debilitating symptom affecting many patients with Parkinson's disease, leading to a reduced mobility and increased risk for falls. Turning is known to be the most provocative trigger for freezing of gait. However, the underlying brain dynamic changes associated with a turning freeze remain unknown. This study therefore used ambulatory EEG to investigate the brain dynamic changes associated with freezing of gait during turning. In addition, this study aimed to determine the most suitable EEG sensor location to detect freezing of gait during turning using our classification system. Data from four Parkinson's disease patients with freezing of gait was analysed using power spectral density and brain effective connectivity, comparing periods of successful turning with freezing of gait during turning. Results showed that freezing of gait during turning is associated with significant alterations in the high beta and theta power spectral densities across the occipital and parietal areas. Furthermore, brain effective connectivity showed that freezing during turning was associated with increased connectivity towards the visual area, which also had the highest accuracy to detect freezing episodes in the O1 regions by using power spectral density in our classification analyses. This is the first study to show cortical dynamic changes associated with freezing of gait during turning, providing valuable information to enhance the performance of future freezing of gait detection systems.

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http://hdl.handle.net/10453/37084