A comprehensive analysis of microsatellite diversity in Aboriginal Australians.

Walsh, SJ; Mitchell, RJ; Watson, N; Buckleton, JS

A comprehensive analysis of microsatellite diversity in Aboriginal Australians.

Walsh, SJ Mitchell, RJ Watson, N Buckleton, JS

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Publication Type:: Journal Article
Citation:: J Hum Genet, 2007, 52 (9), pp. 712 - 728
Issue Date:: 2007

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Field	Value	Language
dc.contributor.author	Walsh, SJ	en_US
dc.contributor.author	Mitchell, RJ	en_US
dc.contributor.author	Watson, N	en_US
dc.contributor.author	Buckleton, JS	en_US
dc.date.available	2007-06-18	en_US
dc.date.issued	2007	en_US
dc.identifier.citation	J Hum Genet, 2007, 52 (9), pp. 712 - 728	en_US
dc.identifier.issn	1434-5161	en_US
dc.identifier.uri	http://hdl.handle.net/10453/3737
dc.description.abstract	Indigenous Australians have a unique evolutionary history that has resulted in a complex system of inter and intra-tribal relationships. While a number of studies have examined the population genetics of indigenous Australians, most have used a single sample to illuminate details of the global dispersal of modern humans and few studies have focussed on the population genetic features of the widely dispersed communities of the indigenous population. In this study we examine the largest Aboriginal Australian sample yet analysed (N = 8,868) at fifteen hypervariable autosomal microsatellite loci. A comprehensive analysis of differentiation indicates different levels of heterogeneity among indigenous peoples from traditional regions of Aboriginal Australia. The most genetically differentiated populations inhabit the North of the country, in particular the Tiwi of Melville and Bathurst islands, Arnhem Land (itself divided into West and East Arnhem), and Fitzmaurice regions. These tribal groups are most differentiated from other Aboriginal Australian tribes, especially those of the Central Desert regions, and also show marked heterogeneity from one another. These genetic findings are supportive of observations of body measurements, skin colour, and dermatoglyphic features which also vary substantially between tribes of the North (e.g. Arnhem Land) and Central Australian regions and, more specifically, between the Tiwi and West and East Arnhem tribes. This study provides the most comprehensive survey of the population genetics of Aboriginal Australia.	en_US
dc.language	eng	en_US
dc.relation.ispartof	J Hum Genet	en_US
dc.relation.isbasedon	10.1007/s10038-007-0172-z	en_US
dc.subject.classification	Genetics & Heredity	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Analysis of Variance	en_US
dc.subject.mesh	Genetics, Population	en_US
dc.subject.mesh	Phylogeny	en_US
dc.subject.mesh	Microsatellite Repeats	en_US
dc.subject.mesh	Heterozygote	en_US
dc.subject.mesh	Geography	en_US
dc.subject.mesh	Oceanic Ancestry Group	en_US
dc.subject.mesh	Ethnic Groups	en_US
dc.subject.mesh	Genetic Variation	en_US
dc.title	A comprehensive analysis of microsatellite diversity in Aboriginal Australians.	en_US
dc.type	Journal Article
utslib.citation.volume	9	en_US
utslib.citation.volume	52	en_US
utslib.location.activity	England	en_US
utslib.for	0699 Other Biological Sciences	en_US
utslib.for	0604 Genetics	en_US
utslib.for	1103 Clinical Sciences	en_US
dc.location.activity	ISI:000249405800002	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Arts and Social Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Arts and Social Sciences/School of Communication
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access
pubs.issue	9	en_US
pubs.publication-status	Published	en_US
pubs.volume	52	en_US

Abstract:

Indigenous Australians have a unique evolutionary history that has resulted in a complex system of inter and intra-tribal relationships. While a number of studies have examined the population genetics of indigenous Australians, most have used a single sample to illuminate details of the global dispersal of modern humans and few studies have focussed on the population genetic features of the widely dispersed communities of the indigenous population. In this study we examine the largest Aboriginal Australian sample yet analysed (N = 8,868) at fifteen hypervariable autosomal microsatellite loci. A comprehensive analysis of differentiation indicates different levels of heterogeneity among indigenous peoples from traditional regions of Aboriginal Australia. The most genetically differentiated populations inhabit the North of the country, in particular the Tiwi of Melville and Bathurst islands, Arnhem Land (itself divided into West and East Arnhem), and Fitzmaurice regions. These tribal groups are most differentiated from other Aboriginal Australian tribes, especially those of the Central Desert regions, and also show marked heterogeneity from one another. These genetic findings are supportive of observations of body measurements, skin colour, and dermatoglyphic features which also vary substantially between tribes of the North (e.g. Arnhem Land) and Central Australian regions and, more specifically, between the Tiwi and West and East Arnhem tribes. This study provides the most comprehensive survey of the population genetics of Aboriginal Australia.

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http://hdl.handle.net/10453/3737