BrachyView, a novel in-body imaging system for HDR prostate brachytherapy: Experimental evaluation

Safavi-Naeini, M; Han, Z; Alnaghy, S; Cutajar, D; Petasecca, M; Lerch, MLF; Franklin, DR; Bucci, J; Carrara, M; Zaider, M; Rosenfeld, AB

BrachyView, a novel in-body imaging system for HDR prostate brachytherapy: Experimental evaluation

Safavi-Naeini, M Han, Z Alnaghy, S Cutajar, D Petasecca, M Lerch, MLF Franklin, DR

Bucci, J Carrara, M Zaider, M Rosenfeld, AB

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Publication Type:: Journal Article
Citation:: Medical Physics, 2015, 42 (12), pp. 7098 - 7107
Issue Date:: 2015-12-01

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Field	Value	Language
dc.contributor.author	Safavi-Naeini, M	en_US
dc.contributor.author	Han, Z	en_US
dc.contributor.author	Alnaghy, S	en_US
dc.contributor.author	Cutajar, D	en_US
dc.contributor.author	Petasecca, M	en_US
dc.contributor.author	Lerch, MLF	en_US
dc.contributor.author	Franklin, DR https://orcid.org/0000-0002-9563-5943	en_US
dc.contributor.author	Bucci, J	en_US
dc.contributor.author	Carrara, M	en_US
dc.contributor.author	Zaider, M	en_US
dc.contributor.author	Rosenfeld, AB	en_US
dc.date.available	2020-05-25T19:19:06Z
dc.date.issued	2015-12-01	en_US
dc.identifier.citation	Medical Physics, 2015, 42 (12), pp. 7098 - 7107	en_US
dc.identifier.issn	0094-2405	en_US
dc.identifier.uri	http://hdl.handle.net/10453/38371
dc.description.abstract	© 2015 American Association of Physicists in Medicine. Purpose: This paper presents initial experimental results from a prototype of high dose rate (HDR) BrachyView, a novel in-body source tracking system for HDR brachytherapy based on a multipinhole tungsten collimator and a high resolution pixellated silicon detector array. The probe and its associated position estimation algorithms are validated and a comprehensive evaluation of the accuracy of its position estimation capabilities is presented. Methods: The HDR brachytherapy source is moved through a sequence of positions in a prostate phantom, for various displacements in x, y, and z. For each position, multiple image acquisitions are performed, and source positions are reconstructed. Error estimates in each dimension are calculated at each source position and combined to calculate overall positioning errors. Gafchromic film is used to validate the accuracy of source placement within the phantom. Results: More than 90% of evaluated source positions were estimated with an error of less than one millimeter, with the worst-case error being 1.3 mm. Experimental results were in close agreement with previously published Monte Carlo simulation results. Conclusions: The prototype of HDR BrachyView demonstrates a satisfactory level of accuracy in its source position estimation, and additional improvements are achievable with further refinement of HDR BrachyView's image processing algorithms.	en_US
dc.relation.ispartof	Medical Physics	en_US
dc.relation.isbasedon	10.1118/1.4935866	en_US
dc.subject.classification	Nuclear Medicine & Medical Imaging	en_US
dc.subject.mesh	Prostate	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Tungsten	en_US
dc.subject.mesh	Silicon	en_US
dc.subject.mesh	Diagnostic Imaging	en_US
dc.subject.mesh	Radiography	en_US
dc.subject.mesh	Brachytherapy	en_US
dc.subject.mesh	Radiotherapy Dosage	en_US
dc.subject.mesh	Equipment Design	en_US
dc.subject.mesh	Radiometry	en_US
dc.subject.mesh	Phantoms, Imaging	en_US
dc.subject.mesh	Algorithms	en_US
dc.subject.mesh	Models, Biological	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Radiotherapy, Image-Guided	en_US
dc.title	BrachyView, a novel in-body imaging system for HDR prostate brachytherapy: Experimental evaluation	en_US
dc.type	Journal Article
utslib.citation.volume	12	en_US
utslib.citation.volume	42	en_US
utslib.for	0299 Other Physical Sciences	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Electrical and Data Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CRIN - Realtime Information Networks
utslib.copyright.status	open_access
pubs.issue	12	en_US
pubs.publication-status	Published	en_US
pubs.volume	42	en_US

Abstract:

© 2015 American Association of Physicists in Medicine. Purpose: This paper presents initial experimental results from a prototype of high dose rate (HDR) BrachyView, a novel in-body source tracking system for HDR brachytherapy based on a multipinhole tungsten collimator and a high resolution pixellated silicon detector array. The probe and its associated position estimation algorithms are validated and a comprehensive evaluation of the accuracy of its position estimation capabilities is presented. Methods: The HDR brachytherapy source is moved through a sequence of positions in a prostate phantom, for various displacements in x, y, and z. For each position, multiple image acquisitions are performed, and source positions are reconstructed. Error estimates in each dimension are calculated at each source position and combined to calculate overall positioning errors. Gafchromic film is used to validate the accuracy of source placement within the phantom. Results: More than 90% of evaluated source positions were estimated with an error of less than one millimeter, with the worst-case error being 1.3 mm. Experimental results were in close agreement with previously published Monte Carlo simulation results. Conclusions: The prototype of HDR BrachyView demonstrates a satisfactory level of accuracy in its source position estimation, and additional improvements are achievable with further refinement of HDR BrachyView's image processing algorithms.

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http://hdl.handle.net/10453/38371