RNA Binding Proteins in the miRNA Pathway
- Publication Type:
- Journal Article
- International Journal of Molecular Sciences, 2016, 17 (31), pp. 1 - 16
- Issue Date:
|dc.identifier.citation||International Journal of Molecular Sciences, 2016, 17 (31), pp. 1 - 16||en_US|
|dc.description.abstract||microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets.||en_US|
|dc.relation.ispartof||International Journal of Molecular Sciences||en_US|
|dc.title||RNA Binding Proteins in the miRNA Pathway||en_US|
|utslib.for||0903 Biomedical Engineering||en_US|
|utslib.for||0399 Other Chemical Sciences||en_US|
|utslib.for||0699 Other Biological Sciences||en_US|
|pubs.organisational-group||/University of Technology Sydney|
|pubs.organisational-group||/University of Technology Sydney/DVC (Teaching and Learning)|
|pubs.organisational-group||/University of Technology Sydney/DVC (Teaching and Learning)/Connected Intelligence Centre|
|pubs.organisational-group||/University of Technology Sydney/Faculty of Engineering and Information Technology|
|pubs.organisational-group||/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering|
|pubs.organisational-group||/University of Technology Sydney/Faculty of Science|
|pubs.organisational-group||/University of Technology Sydney/Strength - CHT - Health Technologies|
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