Trna-derived fragments (Trfs): Emerging new roles for an ancient RNA in the regulation of gene expression

Keam, SP; Hutvagner, G

Trna-derived fragments (Trfs): Emerging new roles for an ancient RNA in the regulation of gene expression

Keam, SP

Hutvagner, G

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Publication Type:: Journal Article
Citation:: Life, 2015, 5 (4), pp. 1638 - 1651
Issue Date:: 2015-11-27

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Field	Value	Language
dc.contributor.author	Keam, SP https://orcid.org/0000-0001-9053-9138	en_US
dc.contributor.author	Hutvagner, G https://orcid.org/0000-0002-7231-9446	en_US
dc.date.available	2015-11-17	en_US
dc.date.issued	2015-11-27	en_US
dc.identifier.citation	Life, 2015, 5 (4), pp. 1638 - 1651	en_US
dc.identifier.uri	http://hdl.handle.net/10453/41452
dc.description.abstract	© 2015 by the authors; licensee MDPI, Basel, Switzerland. This review will summarise the recent discoveries and current state of research on short noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will describe the features of the known subtypes of these RNAs; including sequence characteristics, protein interactors, expression characteristics, biogenesis, and similarity to canonical miRNA pathways. Also their role in regulating gene expression; including mediating translational suppression, will be discussed. We also highlight their potential use as biomarkers, functions in gene regulation and links to disease. Finally, this review will speculate as to the origin and rationale for the conservation of this novel class of noncoding RNAs amongst both prokaryotes and eukaryotes.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DP130103027
dc.relation.ispartof	Life	en_US
dc.relation.isbasedon	10.3390/life5041638	en_US
dc.title	Trna-derived fragments (Trfs): Emerging new roles for an ancient RNA in the regulation of gene expression	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	5	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	5	en_US

Abstract:

© 2015 by the authors; licensee MDPI, Basel, Switzerland. This review will summarise the recent discoveries and current state of research on short noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will describe the features of the known subtypes of these RNAs; including sequence characteristics, protein interactors, expression characteristics, biogenesis, and similarity to canonical miRNA pathways. Also their role in regulating gene expression; including mediating translational suppression, will be discussed. We also highlight their potential use as biomarkers, functions in gene regulation and links to disease. Finally, this review will speculate as to the origin and rationale for the conservation of this novel class of noncoding RNAs amongst both prokaryotes and eukaryotes.

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http://hdl.handle.net/10453/41452