Change in size of lesions over 3 weeks after radiofrequency ablation of left ventricle.

Kovoor, P; Daly, M; Mikhail, M; Eipper, V; Dewsnap, B; Ross, DL

Change in size of lesions over 3 weeks after radiofrequency ablation of left ventricle.

Kovoor, P Daly, M Mikhail, M Eipper, V Dewsnap, B Ross, DL

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Publication Type:: Journal Article
Citation:: J Cardiovasc Electrophysiol, 2006, 17 (4), pp. 411 - 414
Issue Date:: 2006-04

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Field	Value	Language
dc.contributor.author	Kovoor, P	en_US
dc.contributor.author	Daly, M	en_US
dc.contributor.author	Mikhail, M	en_US
dc.contributor.author	Eipper, V	en_US
dc.contributor.author	Dewsnap, B	en_US
dc.contributor.author	Ross, DL	en_US
dc.date.issued	2006-04	en_US
dc.identifier.citation	J Cardiovasc Electrophysiol, 2006, 17 (4), pp. 411 - 414	en_US
dc.identifier.issn	1045-3873	en_US
dc.identifier.uri	http://hdl.handle.net/10453/4686
dc.description.abstract	INTRODUCTION: The initial success or failure of radiofrequency ablation (RFA) does not always reflect the long-term outcome that can lead to complications such as late atrioventricular block or recurrence of accessory pathways. We hypothesize that these occurrences may be due to a change in lesion size over time. METHODS AND RESULTS: Intramural RFAs were performed on five greyhounds at thoracotomy using an epicardial approach into the left ventricular (LV) wall. Twenty-one gauge needle electrode ablations were created in the anterior aspect of the left ventricle. Radiofrequency energy was delivered at 600 Hz for 60 seconds and at an electrode temperature of 90 degrees C. Eight ablations were created in each greyhound and the chest was closed. After 3 weeks, a further eight ablations were created under the same conditions in the lateral aspect of the LV, ensuring they were well away from the chronic lesions, and the dogs were sacrificed an hour later. All lesions were removed, stained with Gomori Trichrome and measured. There was no significant difference in lesion size detected in the 1-hour-old lesions compared with 3-week-old lesions. Acute lesions were well demarcated by an area of fibrous scar and a central necrotic region. Chronic lesions showed chronic inflammatory cells and strands of collagen. CONCLUSIONS: This study shows no change in lesion dimension over time and hence a change in size may not contribute to a change in RFA outcome over time.	en_US
dc.language	eng	en_US
dc.relation.ispartof	J Cardiovasc Electrophysiol	en_US
dc.relation.isbasedon	10.1111/j.1540-8167.2006.00428.x	en_US
dc.subject.classification	Cardiovascular System & Hematology	en_US
dc.subject.mesh	Heart Ventricles	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Dogs	en_US
dc.subject.mesh	Tachycardia, Ventricular	en_US
dc.subject.mesh	Disease Models, Animal	en_US
dc.subject.mesh	Catheter Ablation	en_US
dc.subject.mesh	Treatment Outcome	en_US
dc.subject.mesh	Follow-Up Studies	en_US
dc.subject.mesh	Time Factors	en_US
dc.title	Change in size of lesions over 3 weeks after radiofrequency ablation of left ventricle.	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	17	en_US
utslib.location.activity	United States	en_US
utslib.for	1102 Cardiorespiratory Medicine and Haematology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	17	en_US

Abstract:

INTRODUCTION: The initial success or failure of radiofrequency ablation (RFA) does not always reflect the long-term outcome that can lead to complications such as late atrioventricular block or recurrence of accessory pathways. We hypothesize that these occurrences may be due to a change in lesion size over time. METHODS AND RESULTS: Intramural RFAs were performed on five greyhounds at thoracotomy using an epicardial approach into the left ventricular (LV) wall. Twenty-one gauge needle electrode ablations were created in the anterior aspect of the left ventricle. Radiofrequency energy was delivered at 600 Hz for 60 seconds and at an electrode temperature of 90 degrees C. Eight ablations were created in each greyhound and the chest was closed. After 3 weeks, a further eight ablations were created under the same conditions in the lateral aspect of the LV, ensuring they were well away from the chronic lesions, and the dogs were sacrificed an hour later. All lesions were removed, stained with Gomori Trichrome and measured. There was no significant difference in lesion size detected in the 1-hour-old lesions compared with 3-week-old lesions. Acute lesions were well demarcated by an area of fibrous scar and a central necrotic region. Chronic lesions showed chronic inflammatory cells and strands of collagen. CONCLUSIONS: This study shows no change in lesion dimension over time and hence a change in size may not contribute to a change in RFA outcome over time.

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http://hdl.handle.net/10453/4686