A purposely designed neural signal amplifier for short interval stimulation and recording microneurography using a common electrode

Shek, S; Willey, K; McNulty, PA

A purposely designed neural signal amplifier for short interval stimulation and recording microneurography using a common electrode

Shek, S Willey, K

McNulty, PA

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Publication Type:: Journal Article
Citation:: Journal of Neuroscience Methods, 2006, 152 (1-2), pp. 130 - 135
Issue Date:: 2006-04-15

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Field	Value	Language
dc.contributor.author	Shek, S	en_US
dc.contributor.author	Willey, K https://orcid.org/0000-0003-1478-0346	en_US
dc.contributor.author	McNulty, PA	en_US
dc.date.available	2005-08-30	en_US
dc.date.issued	2006-04-15	en_US
dc.identifier.citation	Journal of Neuroscience Methods, 2006, 152 (1-2), pp. 130 - 135	en_US
dc.identifier.issn	0165-0270	en_US
dc.identifier.uri	http://hdl.handle.net/10453/4777
dc.description.abstract	'Common Electrode' microneurography (i.e. stimulating a nerve and recording return afferent neural activity through the same microelectrode facilitates investigation of linkages between sensory and motor nervous systems in humans. Currently there is no commercial product designed specifically to conduct common electrode microneurography experiments. However, such experiments would advance investigations in several key areas including spinal injury research. In this paper, we report on the successful production and testing (on a human subject) of an integrated amplifier built specifically for this purpose. The amplifier was built using commercially available components to allow for both easy and economical manufacture. In particular, we report on the design requirements and outline our chosen design solutions. The amplifier handles low-level neural signals amidst large 50 Hz interference, with protection against potentially high stimulation voltages of over 100 V dc, with minimal cross-coupling of rapid stimulus pulses onto the high gain amplifier's input, and a short 'blocking' time between stimulation and recording. The amplifier also includes necessary filters, selectable gains and internal stimulator triggering circuits to provide a simple, integrated solution for common electrode operation on human subjects. © 2005 Elsevier B.V. All rights reserved.	en_US
dc.relation.ispartof	Journal of Neuroscience Methods	en_US
dc.relation.isbasedon	10.1016/j.jneumeth.2005.08.019	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Neurons	en_US
dc.subject.mesh	Motor Neurons	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Electromyography	en_US
dc.subject.mesh	Electric Stimulation	en_US
dc.subject.mesh	Microelectrodes	en_US
dc.subject.mesh	Electrophysiology	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Amplifiers, Electronic	en_US
dc.title	A purposely designed neural signal amplifier for short interval stimulation and recording microneurography using a common electrode	en_US
dc.type	Journal Article
utslib.citation.volume	1-2	en_US
utslib.citation.volume	152	en_US
utslib.for	1702 Cognitive Sciences	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1701 Psychology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CRIN - Realtime Information Networks
utslib.copyright.status	closed_access
pubs.declined	1970-01-01T00:00:00.0+1000
pubs.issue	1-2	en_US
pubs.publication-status	Published	en_US
pubs.volume	152	en_US

Abstract:

'Common Electrode' microneurography (i.e. stimulating a nerve and recording return afferent neural activity through the same microelectrode facilitates investigation of linkages between sensory and motor nervous systems in humans. Currently there is no commercial product designed specifically to conduct common electrode microneurography experiments. However, such experiments would advance investigations in several key areas including spinal injury research. In this paper, we report on the successful production and testing (on a human subject) of an integrated amplifier built specifically for this purpose. The amplifier was built using commercially available components to allow for both easy and economical manufacture. In particular, we report on the design requirements and outline our chosen design solutions. The amplifier handles low-level neural signals amidst large 50 Hz interference, with protection against potentially high stimulation voltages of over 100 V dc, with minimal cross-coupling of rapid stimulus pulses onto the high gain amplifier's input, and a short 'blocking' time between stimulation and recording. The amplifier also includes necessary filters, selectable gains and internal stimulator triggering circuits to provide a simple, integrated solution for common electrode operation on human subjects. © 2005 Elsevier B.V. All rights reserved.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/4777