Cancer Exosomes as miRNA Factories

Tran, N

Cancer Exosomes as miRNA Factories

Tran, N

Permalink

Publication Type:: Journal Article
Citation:: Trends in Cancer, 2016, 2 (7), pp. 329 - 331
Issue Date:: 2016-07-01

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Accepted Manuscript VersionAdobe PDF (142.55 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Tran, N https://orcid.org/0000-0001-7747-2530	en_US
dc.date.available	2020-05-25T19:11:28Z
dc.date.issued	2016-07-01	en_US
dc.identifier.citation	Trends in Cancer, 2016, 2 (7), pp. 329 - 331	en_US
dc.identifier.issn	2405-8033	en_US
dc.identifier.uri	http://hdl.handle.net/10453/49453
dc.description.abstract	© 2016 Elsevier Inc. miRNAs modulate gene expression while exosomes are extracellular cargo vessels that transport miRNAs and other materials to surrounding cells. When exosomes are taken up by recipient cells, the released miRNAs can modulate immune responses, inhibit apoptosis, and promote angiogenesis to maintain tumor growth. Central to this regulation is the processing of the primary transcripts into active miRNAs, which occurs exclusively within mammalian cells. Challenging this dogma is the discovery that Dicer and Ago2, key components of miRNA processing, are also present inside exosomes. While the exact nature of this processing requires extensive proof, it is an exciting notion that exogenous miRNA factories could exist outside the canonical boundaries of mammalian cells.	en_US
dc.relation.ispartof	Trends in Cancer	en_US
dc.relation.isbasedon	10.1016/j.trecan.2016.05.008	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Neoplasms	en_US
dc.subject.mesh	MicroRNAs	en_US
dc.subject.mesh	Exosomes	en_US
dc.title	Cancer Exosomes as miRNA Factories	en_US
dc.type	Journal Article
utslib.citation.volume	7	en_US
utslib.citation.volume	2	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	7	en_US
pubs.publication-status	Published	en_US
pubs.volume	2	en_US

Abstract:

© 2016 Elsevier Inc. miRNAs modulate gene expression while exosomes are extracellular cargo vessels that transport miRNAs and other materials to surrounding cells. When exosomes are taken up by recipient cells, the released miRNAs can modulate immune responses, inhibit apoptosis, and promote angiogenesis to maintain tumor growth. Central to this regulation is the processing of the primary transcripts into active miRNAs, which occurs exclusively within mammalian cells. Challenging this dogma is the discovery that Dicer and Ago2, key components of miRNA processing, are also present inside exosomes. While the exact nature of this processing requires extensive proof, it is an exciting notion that exogenous miRNA factories could exist outside the canonical boundaries of mammalian cells.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/49453