Twin-to-twin transfusion syndrome and potential applicability to the Barker hypothesis

Mann, P; Green, J; Walker, K

Twin-to-twin transfusion syndrome and potential applicability to the Barker hypothesis

Mann, P Green, J

Walker, K

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Publication Type:: Journal Article
Citation:: Journal of Neonatal Nursing, 2016, 22 (5), pp. 223 - 227
Issue Date:: 2016-01-01

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Field	Value	Language
dc.contributor.author	Mann, P	en_US
dc.contributor.author	Green, J https://orcid.org/0000-0002-2938-6694	en_US
dc.contributor.author	Walker, K	en_US
dc.date.issued	2016-01-01	en_US
dc.identifier.citation	Journal of Neonatal Nursing, 2016, 22 (5), pp. 223 - 227	en_US
dc.identifier.issn	1355-1841	en_US
dc.identifier.uri	http://hdl.handle.net/10453/54972
dc.description.abstract	© 2016 Twin-to-Twin Transfusion Syndrome (TTTS) carries significant risk of morbidity and mortality in affected monozygotic twin sets. As research into TTTS progresses, the effects of the adverse intrauterine environment on the long-term morbidities of TTTS survivors, is becoming more apparent. In TTTS, there is impaired vascular development and significant cardiac change in both foetuses, leading to high risk of long-term cardiac and neurologic morbidities in survivors. This appears to reflect the Barker Hypothesis of the Developmental Origins of Disease. This review will discuss the Barker Hypothesis and its potential applicability to TTTS. It will outline foetal development in TTTS and subsequent consequences for the neonate. Current TTTS research will be discussed in addition to relevant neonatal care provision. It will become evident that in order to improve long-term outcomes for TTTS survivors, a significant body of research focussing upon the correlation between foetal development in TTTS and associated adult disease states is required.	en_US
dc.relation.ispartof	Journal of Neonatal Nursing	en_US
dc.relation.isbasedon	10.1016/j.jnn.2016.03.002	en_US
dc.subject.classification	Nursing	en_US
dc.title	Twin-to-twin transfusion syndrome and potential applicability to the Barker hypothesis	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	22	en_US
utslib.for	1114 Paediatrics and Reproductive Medicine	en_US
utslib.for	1110 Nursing	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Arts and Social Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	22	en_US

Abstract:

© 2016 Twin-to-Twin Transfusion Syndrome (TTTS) carries significant risk of morbidity and mortality in affected monozygotic twin sets. As research into TTTS progresses, the effects of the adverse intrauterine environment on the long-term morbidities of TTTS survivors, is becoming more apparent. In TTTS, there is impaired vascular development and significant cardiac change in both foetuses, leading to high risk of long-term cardiac and neurologic morbidities in survivors. This appears to reflect the Barker Hypothesis of the Developmental Origins of Disease. This review will discuss the Barker Hypothesis and its potential applicability to TTTS. It will outline foetal development in TTTS and subsequent consequences for the neonate. Current TTTS research will be discussed in addition to relevant neonatal care provision. It will become evident that in order to improve long-term outcomes for TTTS survivors, a significant body of research focussing upon the correlation between foetal development in TTTS and associated adult disease states is required.

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http://hdl.handle.net/10453/54972