Use of benzodiazepines in obsessive-compulsive disorder

Starcevic, V; Berle, D; Do Rosário, MC; Brakoulias, V; Ferrão, YA; Viswasam, K; Shavitt, R; Miguel, E; Fontenelle, LF

Use of benzodiazepines in obsessive-compulsive disorder

Starcevic, V Berle, D

Do Rosário, MC Brakoulias, V Ferrão, YA Viswasam, K Shavitt, R Miguel, E Fontenelle, LF

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Publication Type:: Journal Article
Citation:: International Clinical Psychopharmacology, 2016, 31 (1), pp. 27 - 33
Issue Date:: 2016-01-01

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Field	Value	Language
dc.contributor.author	Starcevic, V	en_US
dc.contributor.author	Berle, D https://orcid.org/0000-0002-4861-2220	en_US
dc.contributor.author	Do Rosário, MC	en_US
dc.contributor.author	Brakoulias, V	en_US
dc.contributor.author	Ferrão, YA	en_US
dc.contributor.author	Viswasam, K	en_US
dc.contributor.author	Shavitt, R	en_US
dc.contributor.author	Miguel, E	en_US
dc.contributor.author	Fontenelle, LF	en_US
dc.date.available	2020-05-25T19:15:24Z
dc.date.issued	2016-01-01	en_US
dc.identifier.citation	International Clinical Psychopharmacology, 2016, 31 (1), pp. 27 - 33	en_US
dc.identifier.issn	0268-1315	en_US
dc.identifier.uri	http://hdl.handle.net/10453/71068
dc.description.abstract	© 2015 Wolters Kluwer Health, Inc. This study aimed to determine the frequency of benzodiazepine (BDZ) use in a large sample of patients with obsessive-compulsive disorder (OCD) and ascertain the type of BDZ used and the correlates and predictors of BDZ use in OCD. The sample consisted of 955 patients with OCD from a comprehensive, cross-sectional, multicentre study conducted by the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders between 2003 and 2009. The rate of BDZ use over time in this OCD sample was 38.4%. Of individuals taking BDZs, 96.7% used them in combination with other medications, usually serotonin reuptake inhibitors. The most commonly used BDZ was clonazepam. Current age, current level of anxiety and number of additional medications for OCD taken over time significantly predicted BDZ use. This is the first study to comprehensively examine BDZ use in OCD patients, demonstrating that it is relatively common, despite recommendations from treatment guidelines. Use of BDZs in combination with several other medications over time and in patients with marked anxiety suggests that OCD patients taking BDZs may be more complex and more difficult to manage. This calls for further research and clarification of the role of BDZs in the treatment of OCD.	en_US
dc.relation.ispartof	International Clinical Psychopharmacology	en_US
dc.relation.isbasedon	10.1097/YIC.0000000000000100	en_US
dc.subject.classification	Psychiatry	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Benzodiazepines	en_US
dc.subject.mesh	Serotonin Uptake Inhibitors	en_US
dc.subject.mesh	Anti-Anxiety Agents	en_US
dc.subject.mesh	Drug Therapy, Combination	en_US
dc.subject.mesh	Cross-Sectional Studies	en_US
dc.subject.mesh	Anxiety	en_US
dc.subject.mesh	Obsessive-Compulsive Disorder	en_US
dc.subject.mesh	Psychiatric Status Rating Scales	en_US
dc.subject.mesh	Socioeconomic Factors	en_US
dc.subject.mesh	Diagnostic and Statistical Manual of Mental Disorders	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Use of benzodiazepines in obsessive-compulsive disorder	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	31	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	1701 Psychology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	31	en_US

Abstract:

© 2015 Wolters Kluwer Health, Inc. This study aimed to determine the frequency of benzodiazepine (BDZ) use in a large sample of patients with obsessive-compulsive disorder (OCD) and ascertain the type of BDZ used and the correlates and predictors of BDZ use in OCD. The sample consisted of 955 patients with OCD from a comprehensive, cross-sectional, multicentre study conducted by the Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders between 2003 and 2009. The rate of BDZ use over time in this OCD sample was 38.4%. Of individuals taking BDZs, 96.7% used them in combination with other medications, usually serotonin reuptake inhibitors. The most commonly used BDZ was clonazepam. Current age, current level of anxiety and number of additional medications for OCD taken over time significantly predicted BDZ use. This is the first study to comprehensively examine BDZ use in OCD patients, demonstrating that it is relatively common, despite recommendations from treatment guidelines. Use of BDZs in combination with several other medications over time and in patients with marked anxiety suggests that OCD patients taking BDZs may be more complex and more difficult to manage. This calls for further research and clarification of the role of BDZs in the treatment of OCD.

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http://hdl.handle.net/10453/71068