Issue Date | Title | Author(s) |
2012-04-01 | The active site residue V266 of chlamydial HtrA is critical for substrate binding during both in vitro and in vivo conditions | Gloeckl, S; Tyndall, JDA; Stansfield, SH; Timms, P; Huston, WM |
2016-08-17 | Chlamydia Serine Protease Inhibitor, targeting HtrA, as a New Treatment for Koala Chlamydia infection | Lawrence, A; Fraser, T; Gillett, A; Tyndall, JDA; Timms, P; Polkinghorne, A; Huston, WM |
2015-09-30 | A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production Microbial genetics, genomics and proteomics | Marsh, JW; Wee, BA; Tyndall, JDA; Lott, WB; Bastidas, RJ; Caldwell, HD; Valdivia, RH; Kari, L; Huston, WM |
2017-07-01 | CtHtrA: The lynchpin of the chlamydial surface and a promising therapeutic target | Marsh, JW; Ong, VA; Lott, WB; Timms, P; Tyndall, JDA; Huston, WM |
2021-12-31 | Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in Chlamydia. | Hwang, J; Strange, N; Mazraani, R; Phillips, MJ; Gamble, AB; Huston, WM; Tyndall, JDA |
2013-08-01 | Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis | Gloeckl, S; Ong, VA; Patel, P; Tyndall, JDA; Timms, P; Beagley, KW; Allan, JA; Armitage, CW; Turnbull, L; Whitchurch, CB; Merdanovic, M; Ehrmann, M; Powers, JC; Oleksyszyn, J; Verdoes, M; Bogyo, M; Huston, WM |
2021-11 | Optimization of peptide-based inhibitors targeting the HtrA serine protease in Chlamydia: Design, synthesis and biological evaluation of pyridone-based and N-Capping group-modified analogues. | Hwang, J; Strange, N; Phillips, MJA; Krause, AL; Heywood, A; Gamble, AB; Huston, WM; Tyndall, JDA |
2018-07-01 | Proteases and protease inhibitors in infectious diseases | Agbowuro, AA; Huston, WM; Gamble, AB; Tyndall, JDA |
2013-12-01 | Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand β5 | Marsh, JW; Lott, WB; Tyndall, JDA; Huston, WWM |
2018-03-22 | Stereochemical basis for the anti-chlamydial activity of the phosphonate protease inhibitor JO146 | Agbowuro, AA; Mazraani, R; McCaughey, LC; Huston, WM; Gamble, AB; Tyndall, JDA |
2019-09-15 | Structure-activity analysis of peptidic Chlamydia HtrA inhibitors | Agbowuro, AA; Hwang, J; Peel, E; Mazraani, R; Springwald, A; Marsh, JW; McCaughey, L; Gamble, AB; Huston, WM; Tyndall, JDA |
2011-09-08 | Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis | Huston, WM; Tyndall, JDA; Lott, WB; Stansfield, SH; Timms, P |