CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target.

Future Medicine
Publication Type:
Journal Article
Future Microbiology, 2017, 12 (9), pp. 817 - 829
Issue Date:
Full metadata record
Files in This Item:
Filename Description Size
MARSH CtHtrA Review FINAL.docxSubmitted Version143.98 kB
Microsoft Word XML
Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection worldwide and the leading cause of preventable blindness. Reports have emerged of treatment failure, suggesting a need to develop new antibiotics to battle Chlamydia infection. One possible candidate for a new treatment is the protease inhibitor JO146, which is an effective anti-Chlamydia agent that targets the CtHtrA protein. CtHtrA is a lynchpin on the chlamydial cell surface due to its essential and multifunctional roles in the bacteria's stress response, replicative phase of development, virulence and outer-membrane protein assembly. This review summarizes the current understanding of CtHtrA function and presents a mechanistic model that highlights CtHtrA as an effective target for anti-Chlamydia drug development.
Please use this identifier to cite or link to this item: