Opioids, Exertion, and Dyspnea: A Review of the Evidence

Johnson, MJ; Hui, D; Currow, DC

Opioids, Exertion, and Dyspnea: A Review of the Evidence

Johnson, MJ Hui, D Currow, DC

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Publication Type:: Journal Article
Citation:: American Journal of Hospice and Palliative Medicine, 2016, 33 (2), pp. 194 - 200
Issue Date:: 2016-03-01

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Field	Value	Language
dc.contributor.author	Johnson, MJ	en_US
dc.contributor.author	Hui, D	en_US
dc.contributor.author	Currow, DC https://orcid.org/0000-0003-1988-1250	en_US
dc.date.issued	2016-03-01	en_US
dc.identifier.citation	American Journal of Hospice and Palliative Medicine, 2016, 33 (2), pp. 194 - 200	en_US
dc.identifier.issn	1049-9091	en_US
dc.identifier.uri	http://hdl.handle.net/10453/105372
dc.description.abstract	© 2014, © The Author(s) 2014. The aim of this paper is to review the evidence for a role for opioids as an intervention for exertion induced breathlessness with regard to exercise tolerance and breathlessness intensity. Current knowledge about exogenous opioids in exertion-induced breathlessness due to disease comes from a variety of phase 2 feasibility or pilot designs with differing duration, doses, drugs, exercise regimes, underlying aetiologies, and outcome measures. They provide interesting data but firm conclusions for either breathlessness severity or exercise endurance cannot be drawn. There are no adequately powered phase 3 trials of opioids which show improved exercise tolerance and/or exertion induced breathlessness. Low dose oral morphine seems well tolerated by most, and is beneficial for breathlessness intensity. Current work to investigate the effect on exercise tolerance is ongoing.	en_US
dc.relation.ispartof	American Journal of Hospice and Palliative Medicine	en_US
dc.relation.isbasedon	10.1177/1049909114552692	en_US
dc.subject.classification	Gerontology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Dyspnea	en_US
dc.subject.mesh	Morphine	en_US
dc.subject.mesh	Analgesics, Opioid	en_US
dc.subject.mesh	Drug Administration Routes	en_US
dc.subject.mesh	Drug Administration Schedule	en_US
dc.subject.mesh	Physical Exertion	en_US
dc.title	Opioids, Exertion, and Dyspnea: A Review of the Evidence	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	33	en_US
utslib.for	1110 Nursing	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	33	en_US

Abstract:

© 2014, © The Author(s) 2014. The aim of this paper is to review the evidence for a role for opioids as an intervention for exertion induced breathlessness with regard to exercise tolerance and breathlessness intensity. Current knowledge about exogenous opioids in exertion-induced breathlessness due to disease comes from a variety of phase 2 feasibility or pilot designs with differing duration, doses, drugs, exercise regimes, underlying aetiologies, and outcome measures. They provide interesting data but firm conclusions for either breathlessness severity or exercise endurance cannot be drawn. There are no adequately powered phase 3 trials of opioids which show improved exercise tolerance and/or exertion induced breathlessness. Low dose oral morphine seems well tolerated by most, and is beneficial for breathlessness intensity. Current work to investigate the effect on exercise tolerance is ongoing.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/105372