Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5- CHRNA3-CHRNB4) interacts with maternal selfreported smoking status during pregnancy to influence birth weight
Tyrrell, J
Huikari, V
Christie, JT
Cavadino, A
Bakker, R
Brion, MJA
Geller, F
Paternoster, L
Myhre, R
Potter, C
Johnson, PCD
Ebrahim, S
Feenstra, B
Hartikainen, AL
Hattersley, AT
Hofman, A
Kaakinen, M
Lowe, LP
Magnus, P
McConnachie, A
Melbye, M
Ng, JWY
Nohr, EA
Power, C
Ring, SM
Sebert, SP
Sengpiel, V
Taal, HR
Watt, GCM
Sattar, N
Relton, CL
Jacobsson, B
Frayling, TM
Sørensen, TIA
Murray, JC
Lawlor, DA
Pennell, CE
Jaddoe, VWV
Hypponen, E
Lowe, WL
Jarvelin, MR
Smith, GD
Freathy, RM
- Publication Type:
- Journal Article
- Citation:
- Human Molecular Genetics, 2012, 21 (24), pp. 5344 - 5358
- Issue Date:
- 2012-12-01
Open Access
Copyright Clearance Process
- Recently Added
- In Progress
- Open Access
This item is open access.
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Tyrrell, J | en_US |
dc.contributor.author | Huikari, V | en_US |
dc.contributor.author | Christie, JT | en_US |
dc.contributor.author | Cavadino, A | en_US |
dc.contributor.author | Bakker, R | en_US |
dc.contributor.author | Brion, MJA | en_US |
dc.contributor.author | Geller, F | en_US |
dc.contributor.author | Paternoster, L | en_US |
dc.contributor.author | Myhre, R | en_US |
dc.contributor.author | Potter, C | en_US |
dc.contributor.author | Johnson, PCD | en_US |
dc.contributor.author | Ebrahim, S | en_US |
dc.contributor.author | Feenstra, B | en_US |
dc.contributor.author | Hartikainen, AL | en_US |
dc.contributor.author | Hattersley, AT | en_US |
dc.contributor.author | Hofman, A | en_US |
dc.contributor.author | Kaakinen, M | en_US |
dc.contributor.author | Lowe, LP | en_US |
dc.contributor.author | Magnus, P | en_US |
dc.contributor.author | McConnachie, A | en_US |
dc.contributor.author | Melbye, M | en_US |
dc.contributor.author | Ng, JWY | en_US |
dc.contributor.author | Nohr, EA | en_US |
dc.contributor.author | Power, C | en_US |
dc.contributor.author | Ring, SM | en_US |
dc.contributor.author | Sebert, SP | en_US |
dc.contributor.author | Sengpiel, V | en_US |
dc.contributor.author | Taal, HR | en_US |
dc.contributor.author | Watt, GCM | en_US |
dc.contributor.author | Sattar, N | en_US |
dc.contributor.author | Relton, CL | en_US |
dc.contributor.author | Jacobsson, B | en_US |
dc.contributor.author | Frayling, TM | en_US |
dc.contributor.author | Sørensen, TIA | en_US |
dc.contributor.author | Murray, JC | en_US |
dc.contributor.author | Lawlor, DA | en_US |
dc.contributor.author | Pennell, CE | en_US |
dc.contributor.author | Jaddoe, VWV | en_US |
dc.contributor.author | Hypponen, E | en_US |
dc.contributor.author | Lowe, WL | en_US |
dc.contributor.author | Jarvelin, MR | en_US |
dc.contributor.author | Smith, GD | en_US |
dc.contributor.author | Freathy, RM | en_US |
dc.date.issued | 2012-12-01 | en_US |
dc.identifier.citation | Human Molecular Genetics, 2012, 21 (24), pp. 5344 - 5358 | en_US |
dc.identifier.issn | 0964-6906 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/113892 | |
dc.description.abstract | Maternal smoking during pregnancy is associated with low birth weight. Common variation at rs1051730 is robustly associated with smoking quantity and was recently shown to influence smoking cessation during pregnancy, but its influence on birth weight is not clear. We aimed to investigate the association between this variant and birth weight of term, singleton offspring in a well-powered meta-analysis. We stratified 26 241 European origin study participants by smoking status (women who smoked during pregnancy versus women who did not smoke during pregnancy) and, in each stratum, analysed the association between maternal rs1051730 genotype and offspring birth weight. There was evidence of interaction between genotype and smoking (P 5 0.007). In women who smoked during pregnancy, each additional smoking-related T-allele was associated with a 20 g [95% confidence interval (95% CI): 4-36 g] lower birth weight (P 5 0.014). However, in women who did not smoke during pregnancy, the effect size estimate was 5 g per T-allele (95% CI: 24 to 14 g; P 5 0.268). To conclude, smoking status during pregnancy modifies the association between maternal rs1051730 genotype and offspring birth weight. This strengthens the evidence that smoking during pregnancy is causally related to lower offspring birth weight and suggests that population interventions that effectively reduce smoking in pregnant women would result in a reduced prevalence of low birth weight. © The Author 2012. Published by Oxford University Press. All rights reserved. | en_US |
dc.relation.ispartof | Human Molecular Genetics | en_US |
dc.relation.isbasedon | 10.1093/hmg/dds372 | en_US |
dc.subject.classification | Genetics & Heredity | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Genetic Predisposition to Disease | en_US |
dc.subject.mesh | Birth Weight | en_US |
dc.subject.mesh | Receptors, Nicotinic | en_US |
dc.subject.mesh | Nerve Tissue Proteins | en_US |
dc.subject.mesh | Smoking | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Infant | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Genetic Variation | en_US |
dc.title | Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5- CHRNA3-CHRNB4) interacts with maternal selfreported smoking status during pregnancy to influence birth weight | en_US |
dc.type | Journal Article | |
utslib.citation.volume | 24 | en_US |
utslib.citation.volume | 21 | en_US |
utslib.for | 06 Biological Sciences | en_US |
utslib.for | 11 Medical and Health Sciences | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health | |
utslib.copyright.status | open_access | |
pubs.issue | 24 | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 21 | en_US |
Abstract:
Maternal smoking during pregnancy is associated with low birth weight. Common variation at rs1051730 is robustly associated with smoking quantity and was recently shown to influence smoking cessation during pregnancy, but its influence on birth weight is not clear. We aimed to investigate the association between this variant and birth weight of term, singleton offspring in a well-powered meta-analysis. We stratified 26 241 European origin study participants by smoking status (women who smoked during pregnancy versus women who did not smoke during pregnancy) and, in each stratum, analysed the association between maternal rs1051730 genotype and offspring birth weight. There was evidence of interaction between genotype and smoking (P 5 0.007). In women who smoked during pregnancy, each additional smoking-related T-allele was associated with a 20 g [95% confidence interval (95% CI): 4-36 g] lower birth weight (P 5 0.014). However, in women who did not smoke during pregnancy, the effect size estimate was 5 g per T-allele (95% CI: 24 to 14 g; P 5 0.268). To conclude, smoking status during pregnancy modifies the association between maternal rs1051730 genotype and offspring birth weight. This strengthens the evidence that smoking during pregnancy is causally related to lower offspring birth weight and suggests that population interventions that effectively reduce smoking in pregnant women would result in a reduced prevalence of low birth weight. © The Author 2012. Published by Oxford University Press. All rights reserved.
Please use this identifier to cite or link to this item:
Download statistics for the last 12 months
Not enough data to produce graph