The relationship between obesity and hypoferraemia in adults: A systematic review

Cheng, HL; Bryant, C; Cook, R; O'Connor, H; Rooney, K; Steinbeck, K

The relationship between obesity and hypoferraemia in adults: A systematic review

Cheng, HL Bryant, C Cook, R

O'Connor, H Rooney, K Steinbeck, K

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Publication Type:: Journal Article
Citation:: Obesity Reviews, 2012, 13 (2), pp. 150 - 161
Issue Date:: 2012-02-01

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Field	Value	Language
dc.contributor.author	Cheng, HL	en_US
dc.contributor.author	Bryant, C	en_US
dc.contributor.author	Cook, R https://orcid.org/0000-0002-9802-3766	en_US
dc.contributor.author	O'Connor, H	en_US
dc.contributor.author	Rooney, K	en_US
dc.contributor.author	Steinbeck, K	en_US
dc.date.issued	2012-02-01	en_US
dc.identifier.citation	Obesity Reviews, 2012, 13 (2), pp. 150 - 161	en_US
dc.identifier.issn	1467-7881	en_US
dc.identifier.uri	http://hdl.handle.net/10453/114949
dc.description.abstract	Summary: A growing number of studies suggest a potential link between obesity and altered iron metabolism. The purpose of this systematic review was to examine existing literature on iron status in obese populations. A comprehensive literature search was conducted. Included studies recruited participants≥18years with a body mass index≥30kgm -2 and provided descriptive statistics for haemoglobin or ferritin at a minimum. There were 25 studies meeting all eligibility criteria, of these 10 examined iron status in free-living obese individuals and 15 reported baseline iron biomarkers from bariatric surgery candidates. Non-obese comparison groups were used by 10 (40%) articles. In these, seven obese groups reported higher mean haemoglobin concentration; six reported significantly higher ferritin concentration; and four significantly lower transferrin saturation. Due to insufficient data, it was not possible to make conclusions regarding mean differences for soluble transferrin receptor (sTfR), hepcidin or C-reactive protein. Existing evidence suggests a tendency for higher haemoglobin and ferritin concentration and lower transferrin saturation in obesity. Alternation of iron biomarkers in obese populations may be a result of obesity-related inflammation and/or related comorbidities. Further research incorporating measurement of inflammatory cytokines, sTfR and hepcidin is required to confirm the impact of obesity on iron status. © 2011 The Authors. obesity reviews © 2011 International Association for the Study of Obesity.	en_US
dc.relation.ispartof	Obesity Reviews	en_US
dc.relation.isbasedon	10.1111/j.1467-789X.2011.00938.x	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Obesity	en_US
dc.subject.mesh	Body Weight	en_US
dc.subject.mesh	Iron	en_US
dc.subject.mesh	C-Reactive Protein	en_US
dc.subject.mesh	Transferrin	en_US
dc.subject.mesh	Hemoglobins	en_US
dc.subject.mesh	Receptors, Transferrin	en_US
dc.subject.mesh	Body Mass Index	en_US
dc.subject.mesh	Ferritins	en_US
dc.title	The relationship between obesity and hypoferraemia in adults: A systematic review	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	13	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	13	en_US

Abstract:

Summary: A growing number of studies suggest a potential link between obesity and altered iron metabolism. The purpose of this systematic review was to examine existing literature on iron status in obese populations. A comprehensive literature search was conducted. Included studies recruited participants≥18years with a body mass index≥30kgm -2 and provided descriptive statistics for haemoglobin or ferritin at a minimum. There were 25 studies meeting all eligibility criteria, of these 10 examined iron status in free-living obese individuals and 15 reported baseline iron biomarkers from bariatric surgery candidates. Non-obese comparison groups were used by 10 (40%) articles. In these, seven obese groups reported higher mean haemoglobin concentration; six reported significantly higher ferritin concentration; and four significantly lower transferrin saturation. Due to insufficient data, it was not possible to make conclusions regarding mean differences for soluble transferrin receptor (sTfR), hepcidin or C-reactive protein. Existing evidence suggests a tendency for higher haemoglobin and ferritin concentration and lower transferrin saturation in obesity. Alternation of iron biomarkers in obese populations may be a result of obesity-related inflammation and/or related comorbidities. Further research incorporating measurement of inflammatory cytokines, sTfR and hepcidin is required to confirm the impact of obesity on iron status. © 2011 The Authors. obesity reviews © 2011 International Association for the Study of Obesity.

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http://hdl.handle.net/10453/114949