Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence

Golledge, J; Clancy, P; Maguire, J; Lincz, L; Koblar, S; Mcevoy, M; Attia, J; Levi, C; Sturm, J; Almeida, OP; Yeap, BB; Flicker, L; Norman, PE; Hankey, GJ

Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence

Golledge, J Clancy, P Maguire, J

Lincz, L Koblar, S Mcevoy, M Attia, J Levi, C Sturm, J Almeida, OP Yeap, BB Flicker, L Norman, PE Hankey, GJ

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Publication Type:: Journal Article
Citation:: Stroke, 2014, 45 (4), pp. 1064 - 1068
Issue Date:: 2014-01-01

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Field	Value	Language
dc.contributor.author	Golledge, J	en_US
dc.contributor.author	Clancy, P	en_US
dc.contributor.author	Maguire, J https://orcid.org/0000-0001-5722-8311	en_US
dc.contributor.author	Lincz, L	en_US
dc.contributor.author	Koblar, S	en_US
dc.contributor.author	Mcevoy, M	en_US
dc.contributor.author	Attia, J	en_US
dc.contributor.author	Levi, C	en_US
dc.contributor.author	Sturm, J	en_US
dc.contributor.author	Almeida, OP	en_US
dc.contributor.author	Yeap, BB	en_US
dc.contributor.author	Flicker, L	en_US
dc.contributor.author	Norman, PE	en_US
dc.contributor.author	Hankey, GJ	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Stroke, 2014, 45 (4), pp. 1064 - 1068	en_US
dc.identifier.issn	0039-2499	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115556
dc.description.abstract	BACKGROUND AND PURPOSE - : Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome. METHODS - : Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined. RESULTS - : Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26-9.53 compared with 17.36; interquartile range, 14.01-22.46 ng/mL; P<0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81-8.75 ng/mL for modified Rankin scale 3-6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75-9.92 ng/mL for modified Rankin scale 0-2; n=194), P=0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men. CONCLUSIONS - : Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes. © 2014 American Heart Association, Inc.	en_US
dc.relation.ispartof	Stroke	en_US
dc.relation.isbasedon	10.1161/STROKEAHA.113.004339	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Brain Ischemia	en_US
dc.subject.mesh	Angiopoietin-1	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Biomarkers	en_US
dc.subject.mesh	Case-Control Studies	en_US
dc.subject.mesh	Disability Evaluation	en_US
dc.subject.mesh	Follow-Up Studies	en_US
dc.subject.mesh	Incidence	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Predictive Value of Tests	en_US
dc.subject.mesh	Prospective Studies	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Severity of Illness Index	en_US
dc.subject.mesh	Stroke	en_US
dc.title	Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	45	en_US
utslib.for	1102 Cardiorespiratory Medicine and Haematology	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1109 Neurosciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	45	en_US

Abstract:

BACKGROUND AND PURPOSE - : Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome. METHODS - : Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined. RESULTS - : Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26-9.53 compared with 17.36; interquartile range, 14.01-22.46 ng/mL; P<0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81-8.75 ng/mL for modified Rankin scale 3-6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75-9.92 ng/mL for modified Rankin scale 0-2; n=194), P=0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men. CONCLUSIONS - : Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes. © 2014 American Heart Association, Inc.

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http://hdl.handle.net/10453/115556