What determines adherence to treatment in cardiovascular disease prevention? Protocol for a mixed methods preference study

Jan, S; Usherwood, T; Brien, JA; Peiris, D; Rose, J; Hayman, N; Howard, K; Redfern, J; Laba, T; Cass, A; Patel, A

What determines adherence to treatment in cardiovascular disease prevention? Protocol for a mixed methods preference study

Jan, S Usherwood, T Brien, JA Peiris, D Rose, J Hayman, N Howard, K Redfern, J Laba, T

Cass, A Patel, A

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Publication Type:: Journal Article
Citation:: BMJ Open, 2011, 1 (2)
Issue Date:: 2011-11-21

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Field	Value	Language
dc.contributor.author	Jan, S	en_US
dc.contributor.author	Usherwood, T	en_US
dc.contributor.author	Brien, JA	en_US
dc.contributor.author	Peiris, D	en_US
dc.contributor.author	Rose, J	en_US
dc.contributor.author	Hayman, N	en_US
dc.contributor.author	Howard, K	en_US
dc.contributor.author	Redfern, J	en_US
dc.contributor.author	Laba, T https://orcid.org/0000-0002-5182-9092	en_US
dc.contributor.author	Cass, A	en_US
dc.contributor.author	Patel, A	en_US
dc.date.issued	2011-11-21	en_US
dc.identifier.citation	BMJ Open, 2011, 1 (2)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/116305
dc.description.abstract	Background: Significant gaps exist between guidelinesrecommended therapies for cardiovascular disease prevention and current practice. Fixed-dose combination pills ('polypills') potentially improve adherence to therapy. This study is a preference study undertaken in conjunction with a clinical trial of a polypill and seeks to examine the underlying reasons for variations in treatment adherence to recommended therapy. Methods/design: A preference study comprising: (1) Discrete Choice Experiment for patients; and (2) qualitative study of patients and providers. Both components will be conducted on participants in the trial. A joint model combining the observed adherence in the clinical trial (revealed preference) and the Discrete Choice Experiment data (stated preference) will be estimated. Estimates will be made of the marginal effect (importance) of each attribute on overall choice, the extent to which respondents are prepared to trade-off one attribute for another and predicted values of the level of adherence given a fixed set of attributes, and contextual and socio-demographic characteristics. For the qualitative study, a thematic analysis will be used as a means of exploring in depth the preferences and ultimately provide important narratives on the experiences and perspectives of individuals with regard to adherence behaviour. Ethics and dissemination: Primary ethics approval was received from Sydney South West Area Health Service Human Research Ethics Committee (Royal Prince Alfred Hospital zone). In addition to usual scientific forums, the findings will be reported back to the communities involved in the studies through sitespecific reports and oral presentations.	en_US
dc.relation.ispartof	BMJ Open	en_US
dc.relation.isbasedon	10.1136/bmjopen-2011-000372	en_US
dc.title	What determines adherence to treatment in cardiovascular disease prevention? Protocol for a mixed methods preference study	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	1	en_US
utslib.for	1117 Public Health and Health Services	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1199 Other Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Business
pubs.organisational-group	/University of Technology Sydney/Strength - BIDA - Business Intelligence and Data Analytics
pubs.organisational-group	/University of Technology Sydney/Strength - CHERE - Centre for Health Economics Research and Evaluation
utslib.copyright.status	open_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	1	en_US

Abstract:

Background: Significant gaps exist between guidelinesrecommended therapies for cardiovascular disease prevention and current practice. Fixed-dose combination pills ('polypills') potentially improve adherence to therapy. This study is a preference study undertaken in conjunction with a clinical trial of a polypill and seeks to examine the underlying reasons for variations in treatment adherence to recommended therapy. Methods/design: A preference study comprising: (1) Discrete Choice Experiment for patients; and (2) qualitative study of patients and providers. Both components will be conducted on participants in the trial. A joint model combining the observed adherence in the clinical trial (revealed preference) and the Discrete Choice Experiment data (stated preference) will be estimated. Estimates will be made of the marginal effect (importance) of each attribute on overall choice, the extent to which respondents are prepared to trade-off one attribute for another and predicted values of the level of adherence given a fixed set of attributes, and contextual and socio-demographic characteristics. For the qualitative study, a thematic analysis will be used as a means of exploring in depth the preferences and ultimately provide important narratives on the experiences and perspectives of individuals with regard to adherence behaviour. Ethics and dissemination: Primary ethics approval was received from Sydney South West Area Health Service Human Research Ethics Committee (Royal Prince Alfred Hospital zone). In addition to usual scientific forums, the findings will be reported back to the communities involved in the studies through sitespecific reports and oral presentations.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/116305