Hepatitis B virus surface antigen (HBsAg)-positive and HBsAg-negative hepatitis B virus infection among mother-teenager pairs 13 years after neonatal hepatitis B virus vaccination

Yao, QQ; Dong, XL; Wang, XC; Ge, SX; Hu, AQ; Liu, HY; Wang, YA; Yuan, Q; Zheng, YJ

Hepatitis B virus surface antigen (HBsAg)-positive and HBsAg-negative hepatitis B virus infection among mother-teenager pairs 13 years after neonatal hepatitis B virus vaccination

Yao, QQ Dong, XL Wang, XC Ge, SX Hu, AQ Liu, HY Wang, YA

Yuan, Q Zheng, YJ

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Publication Type:: Journal Article
Citation:: Clinical and Vaccine Immunology, 2013, 20 (2), pp. 269 - 275
Issue Date:: 2013-02-01

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Field	Value	Language
dc.contributor.author	Yao, QQ	en_US
dc.contributor.author	Dong, XL	en_US
dc.contributor.author	Wang, XC	en_US
dc.contributor.author	Ge, SX	en_US
dc.contributor.author	Hu, AQ	en_US
dc.contributor.author	Liu, HY	en_US
dc.contributor.author	Wang, YA https://orcid.org/0000-0002-3656-4284	en_US
dc.contributor.author	Yuan, Q	en_US
dc.contributor.author	Zheng, YJ	en_US
dc.date.issued	2013-02-01	en_US
dc.identifier.citation	Clinical and Vaccine Immunology, 2013, 20 (2), pp. 269 - 275	en_US
dc.identifier.issn	1556-6811	en_US
dc.identifier.uri	http://hdl.handle.net/10453/116530
dc.description.abstract	It is unclear whether a mother who is negative for hepatitis B virus surface antigen (HBsAg) but positive for hepatitis B virus (HBV) is at potential risk for mother-to-child transmission of HBV. This study, using a paired mother-teenager population, aimed to assess whether maternal HBsAg-negative HBV infection (hnHBI) is a significant source of child HBV infection (HBI). A follow-up study with blood collection has been conducted on the 93 mother-teenager pairs from the initial 135 pregnant womannewborn pairs 13 years after neonatal HBV vaccination. Serological and viral markers of HBV have been tested, and phylogenetic analysis of HBV isolates has been done. The HBI prevalence was 1.9% (1 hnHBI/53) for teenage children of non-HBI mothers, compared with 16.7% (1 hnHBI/6) for those of hnHBI mothers and 2.9% (1 HBsAg-positive HBV infection [ hpHBI]/34) for those of hpHBI mothers. Similar viral sequences have been found in one pair of whom both the mother and teenager have had hnHBI. In comparison with the hpHBI cases, those with hnHBI had a lower level of HBV load and a higher proportion of genotype-C strains, which were accompanied by differentiated mutations (Q129R, K141E, and Y161N) of the "a" determinant of the HBV surface gene. Our findings suggest that mother-to-teenager transmission of hnHBI can occur among those in the neonatal HBV vaccination program. Copyright © 2013, American Society for Microbiology. All Rights Reserved.	en_US
dc.relation.ispartof	Clinical and Vaccine Immunology	en_US
dc.relation.isbasedon	10.1128/CVI.00539-12	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.classification	Immunology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Hepatitis B virus	en_US
dc.subject.mesh	Hepatitis B	en_US
dc.subject.mesh	DNA, Viral	en_US
dc.subject.mesh	Hepatitis B Vaccines	en_US
dc.subject.mesh	Hepatitis B Antibodies	en_US
dc.subject.mesh	Hepatitis B Surface Antigens	en_US
dc.subject.mesh	Vaccination	en_US
dc.subject.mesh	Questionnaires	en_US
dc.subject.mesh	Follow-Up Studies	en_US
dc.subject.mesh	Sequence Analysis, DNA	en_US
dc.subject.mesh	Mothers	en_US
dc.subject.mesh	Phylogeny	en_US
dc.subject.mesh	Base Sequence	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Infectious Disease Transmission, Vertical	en_US
dc.subject.mesh	Surveys and Questionnaires	en_US
dc.title	Hepatitis B virus surface antigen (HBsAg)-positive and HBsAg-negative hepatitis B virus infection among mother-teenager pairs 13 years after neonatal hepatitis B virus vaccination	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	20	en_US
utslib.for	1107 Immunology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Public Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	20	en_US

Abstract:

It is unclear whether a mother who is negative for hepatitis B virus surface antigen (HBsAg) but positive for hepatitis B virus (HBV) is at potential risk for mother-to-child transmission of HBV. This study, using a paired mother-teenager population, aimed to assess whether maternal HBsAg-negative HBV infection (hnHBI) is a significant source of child HBV infection (HBI). A follow-up study with blood collection has been conducted on the 93 mother-teenager pairs from the initial 135 pregnant womannewborn pairs 13 years after neonatal HBV vaccination. Serological and viral markers of HBV have been tested, and phylogenetic analysis of HBV isolates has been done. The HBI prevalence was 1.9% (1 hnHBI/53) for teenage children of non-HBI mothers, compared with 16.7% (1 hnHBI/6) for those of hnHBI mothers and 2.9% (1 HBsAg-positive HBV infection [ hpHBI]/34) for those of hpHBI mothers. Similar viral sequences have been found in one pair of whom both the mother and teenager have had hnHBI. In comparison with the hpHBI cases, those with hnHBI had a lower level of HBV load and a higher proportion of genotype-C strains, which were accompanied by differentiated mutations (Q129R, K141E, and Y161N) of the "a" determinant of the HBV surface gene. Our findings suggest that mother-to-teenager transmission of hnHBI can occur among those in the neonatal HBV vaccination program. Copyright © 2013, American Society for Microbiology. All Rights Reserved.

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http://hdl.handle.net/10453/116530