A systematic review and meta-analysis of mindfulness-based stress reduction for the fibromyalgia syndrome

Publication Type:
Journal Article
Citation:
Journal of Psychosomatic Research, 2013, 75 (6), pp. 500 - 510
Issue Date:
2013-12-01
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Objectives: This paper presents a systematic review and meta-analysis of the effectiveness of mindfulness-based stress reduction (MBSR) for FMS. Methods: The PubMed/MEDLINE, Cochrane Library, EMBASE, PsychINFO and CAMBASE databases were screened in September 2013 to identify randomized and non-randomized controlled trials comparing MBSR to control interventions. Major outcome measures were quality of life and pain; secondary outcomes included sleep quality, fatigue, depression and safety. Standardized mean differences and 95% confidence intervals were calculated. Results: Six trials were located with a total of 674 FMS patients. Analyses revealed low quality evidence for short-term improvement of quality of life (SMD. = -0.35; 95% CI - 0.57 to - 0.12; P. = 0.002) and pain (SMD. = - 0.23; 95% CI - 0.46 to - 0.01; P. = 0.04) after MBSR, when compared to usual care; and for short-term improvement of quality of life (SMD. = - 0.32; 95% CI - 0.59 to - 0.04; P. = 0.02) and pain (SMD. = - 0.44; 95% CI - 0.73 to - 0.16; P. = 0.002) after MBSR, when compared to active control interventions. Effects were not robust against bias. No evidence was further found for secondary outcomes or long-term effects of MBSR. Safety data were not reported in any trial. Conclusions: This systematic review found that MBSR might be a useful approach for FMS patients. According to the quality of evidence only a weak recommendation for MBSR can be made at this point. Further high quality RCTs are required for a conclusive judgment of its effects. © 2013 Elsevier Inc.
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