Effect of alteration in pump speed on pump output and left ventricular filling with continuous-flow left ventricular assist device

Hayward, CS; Salamonsen, R; Keogh, AM; Woodard, J; Ayre, P; Prichard, R; Walker, R; Kotlyar, E; MacDonald, PS; Jansz, P; Spratt, P

Effect of alteration in pump speed on pump output and left ventricular filling with continuous-flow left ventricular assist device

Hayward, CS Salamonsen, R Keogh, AM Woodard, J Ayre, P Prichard, R

Walker, R Kotlyar, E MacDonald, PS Jansz, P Spratt, P

Permalink

Publication Type:: Journal Article
Citation:: ASAIO Journal, 2011, 57 (6), pp. 495 - 500
Issue Date:: 2011-11-01

Closed Access

	Filename	Description	Size
	Effect_of_Alteration_in_Pump_Speed_on_Pump_Output.3(2).pdf	Published Version	886.49 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Hayward, CS	en_US
dc.contributor.author	Salamonsen, R	en_US
dc.contributor.author	Keogh, AM	en_US
dc.contributor.author	Woodard, J	en_US
dc.contributor.author	Ayre, P	en_US
dc.contributor.author	Prichard, R https://orcid.org/0000-0001-8057-6605	en_US
dc.contributor.author	Walker, R	en_US
dc.contributor.author	Kotlyar, E	en_US
dc.contributor.author	MacDonald, PS	en_US
dc.contributor.author	Jansz, P	en_US
dc.contributor.author	Spratt, P	en_US
dc.date.issued	2011-11-01	en_US
dc.identifier.citation	ASAIO Journal, 2011, 57 (6), pp. 495 - 500	en_US
dc.identifier.issn	1058-2916	en_US
dc.identifier.uri	http://hdl.handle.net/10453/117378
dc.description.abstract	Third-generation continuous-flow left ventricular assist devices (LVAD) provide reduced pulsatility flow. We examined the safe working range for LVAD pump speed and the effect on pump output and cardiac function in 13 stable outpatients with VentrAssist-LVAD (Ventracor Ltd, Australia). Pump speed was decreased from a baseline mean of 2,073 ± 86 revolutions per minute (RPM, with corresponding mean flow of 5.59 ± 1.18 L/min, mean ± standard deviation) to an average low-speed of 1,835 ± 55 RPM (corresponding flow 4.68 ± 0.99 L/min) and up to high-speed of 2,315 ± 66 RPM (corresponding flow 6.30 ± 1.29 L/min). There was a strong linear relationship between alteration in speed and flow rates (r = 0.89, p < 0.00001) but marked interpatient variation. Downward titration to preset minimum 1,800 RPM was achieved in 9/13 (69%) and upward titration to the preset maximum 2,400 RPM was achieved in 4/13 (31%). Upward titration was stopped due to ventricular suction or nonsustained ventricular tachycardia (VT) in 4/13 (31%). Ventricular suction or VT (in 4/13) tended to be more common in patients with poor right ventricular (RV) function (p = 0.07). In summary, pump flow is stable within a relatively small speed range and should not be altered without close monitoring due to variation in response between patients, particularly with concomitant RV impairment. Copyright © 2011 by the American Society for Artificial Internal Organs.	en_US
dc.relation.ispartof	ASAIO Journal	en_US
dc.relation.isbasedon	10.1097/MAT.0b013e318233b112	en_US
dc.subject.classification	Biomedical Engineering	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Heart-Assist Devices	en_US
dc.subject.mesh	Coronary Circulation	en_US
dc.subject.mesh	Ventricular Function, Left	en_US
dc.subject.mesh	Pulsatile Flow	en_US
dc.subject.mesh	Adolescent	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Hemodynamics	en_US
dc.subject.mesh	Young Adult	en_US
dc.title	Effect of alteration in pump speed on pump output and left ventricular filling with continuous-flow left ventricular assist device	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	57	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	closed_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	57	en_US

Abstract:

Third-generation continuous-flow left ventricular assist devices (LVAD) provide reduced pulsatility flow. We examined the safe working range for LVAD pump speed and the effect on pump output and cardiac function in 13 stable outpatients with VentrAssist-LVAD (Ventracor Ltd, Australia). Pump speed was decreased from a baseline mean of 2,073 ± 86 revolutions per minute (RPM, with corresponding mean flow of 5.59 ± 1.18 L/min, mean ± standard deviation) to an average low-speed of 1,835 ± 55 RPM (corresponding flow 4.68 ± 0.99 L/min) and up to high-speed of 2,315 ± 66 RPM (corresponding flow 6.30 ± 1.29 L/min). There was a strong linear relationship between alteration in speed and flow rates (r = 0.89, p < 0.00001) but marked interpatient variation. Downward titration to preset minimum 1,800 RPM was achieved in 9/13 (69%) and upward titration to the preset maximum 2,400 RPM was achieved in 4/13 (31%). Upward titration was stopped due to ventricular suction or nonsustained ventricular tachycardia (VT) in 4/13 (31%). Ventricular suction or VT (in 4/13) tended to be more common in patients with poor right ventricular (RV) function (p = 0.07). In summary, pump flow is stable within a relatively small speed range and should not be altered without close monitoring due to variation in response between patients, particularly with concomitant RV impairment. Copyright © 2011 by the American Society for Artificial Internal Organs.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/117378