Health of children born to mothers who had preeclampsia: a population-based cohort study

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Journal Article
American Journal of Obstetrics and Gynecology, 2009, 201 (3), pp. 269.e1 - 269.e10
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Objective: We assessed whether preeclampsia correlates with the long-term postnatal health of the offspring. Study Design: We conducted a population-based cohort study of 1,618,481 singletons born in Denmark (1978-2004) with up to 27 years of follow-up. We used Cox regression to estimate the associations between preeclampsia and long-term health outcomes of the offspring. Results: Children born at term exposed to preeclampsia had an increased risk of a variety of diseases, such as endocrine, nutritional, and metabolic diseases (incidence rate ratio, 1.6; 95% confidence interval, 1.5-1.7), and diseases of the blood and blood-forming organs (incidence rate ratio, 1.5; 95% confidence interval, 1.3-1.8). Children born preterm exposed to preeclampsia had a similar pattern of hospitalizations compared with the children born preterm unexposed to preeclampsia, although they had a decreased risk of cerebral palsy (incidence rate ratio, 0.7; 95% confidence interval, 0.6-0.9). Conclusion: Preeclampsia was associated with an increased risk of being hospitalized for a number of diseases, especially in the children born at term. © 2009 Mosby, Inc. All rights reserved.
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