Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer

Hong, AM; Dobbins, TA; Lee, CS; Jones, D; Fei, J; Clark, JR; Armstrong, BK; Harnett, GB; Milross, CG; Tran, N; Peculis, LD; Ng, C; Milne, AG; Loo, C; Hughes, LJ; Forstner, DF; O'Brien, CJ; Rose, BR

Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer

Hong, AM Dobbins, TA Lee, CS Jones, D Fei, J Clark, JR Armstrong, BK Harnett, GB Milross, CG Tran, N

Peculis, LD Ng, C Milne, AG Loo, C Hughes, LJ Forstner, DF O'Brien, CJ Rose, BR

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Publication Type:: Journal Article
Citation:: International Journal of Cancer, 2011, 128 (7), pp. 1532 - 1545
Issue Date:: 2011-04-01

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Field	Value	Language
dc.contributor.author	Hong, AM	en_US
dc.contributor.author	Dobbins, TA	en_US
dc.contributor.author	Lee, CS	en_US
dc.contributor.author	Jones, D	en_US
dc.contributor.author	Fei, J	en_US
dc.contributor.author	Clark, JR	en_US
dc.contributor.author	Armstrong, BK	en_US
dc.contributor.author	Harnett, GB	en_US
dc.contributor.author	Milross, CG	en_US
dc.contributor.author	Tran, N https://orcid.org/0000-0001-7747-2530	en_US
dc.contributor.author	Peculis, LD	en_US
dc.contributor.author	Ng, C	en_US
dc.contributor.author	Milne, AG	en_US
dc.contributor.author	Loo, C	en_US
dc.contributor.author	Hughes, LJ	en_US
dc.contributor.author	Forstner, DF	en_US
dc.contributor.author	O'Brien, CJ	en_US
dc.contributor.author	Rose, BR	en_US
dc.date.available	2010-05-05	en_US
dc.date.issued	2011-04-01	en_US
dc.identifier.citation	International Journal of Cancer, 2011, 128 (7), pp. 1532 - 1545	en_US
dc.identifier.issn	0020-7136	en_US
dc.identifier.uri	http://hdl.handle.net/10453/117462
dc.description.abstract	There is increasing use of multiple molecular markers to predict prognosis in human cancer. Our aim was to examine the prognostic significance of cyclin D1 and retinoblastoma (pRb) expression in association with human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma. Clinical records and specimens of 226 patients with follow-up from 1 to 235 months postdiagnosis were retrieved. Tumor HPV status was determined by HPV E6-targeted multiplex real-time PCR/p16 semiquantitative immunohistochemistry and cyclin D1 and pRb expression by semiquantitative immunohistochemistry. Determinants of recurrence and mortality hazards were modeled using Cox regression with censoring at dates of last follow-up. The HPV-positivity rate was 37% (91% type 16). HPV was a predictor of recurrence, an event (recurrence or death) and death after adjustment for clinicopathological variables. There were inverse relationships between HPV status and cyclin D1 and pRb. On univariate analysis, cyclin D1 predicted locoregional recurrence, event and death and pRb predicted event and death. Within the HPV-positive group, after adjusting for clinicopathological factors, patients with cyclin D1-positive cancers had up to a eightfold increased risk of poor outcome relative to those with cyclin D1-negative tumors. However, within the HPV-negative group, there was only a very small adjusted increased risk. A combination of pRb and HPV did not provide additional prognostic information. Our data provide the first evidence that a combination of HPV and cyclin D1 provides more prognostic information in oropharyngeal cancer than HPV alone. If findings are confirmed, treatment based on HPV and cyclin D1 may improve outcomes. Copyright © 2010 UICC.	en_US
dc.relation.ispartof	International Journal of Cancer	en_US
dc.relation.isbasedon	10.1002/ijc.25479	en_US
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Oncology & Carcinogenesis	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Papillomavirus Infections	en_US
dc.subject.mesh	Carcinoma, Squamous Cell	en_US
dc.subject.mesh	Oropharyngeal Neoplasms	en_US
dc.subject.mesh	Recurrence	en_US
dc.subject.mesh	Cyclin D1	en_US
dc.subject.mesh	Retinoblastoma Protein	en_US
dc.subject.mesh	Prognosis	en_US
dc.subject.mesh	Treatment Outcome	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer	en_US
dc.type	Journal Article
utslib.citation.volume	7	en_US
utslib.citation.volume	128	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access	*
pubs.issue	7	en_US
pubs.publication-status	Published	en_US
pubs.volume	128	en_US

Abstract:

There is increasing use of multiple molecular markers to predict prognosis in human cancer. Our aim was to examine the prognostic significance of cyclin D1 and retinoblastoma (pRb) expression in association with human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma. Clinical records and specimens of 226 patients with follow-up from 1 to 235 months postdiagnosis were retrieved. Tumor HPV status was determined by HPV E6-targeted multiplex real-time PCR/p16 semiquantitative immunohistochemistry and cyclin D1 and pRb expression by semiquantitative immunohistochemistry. Determinants of recurrence and mortality hazards were modeled using Cox regression with censoring at dates of last follow-up. The HPV-positivity rate was 37% (91% type 16). HPV was a predictor of recurrence, an event (recurrence or death) and death after adjustment for clinicopathological variables. There were inverse relationships between HPV status and cyclin D1 and pRb. On univariate analysis, cyclin D1 predicted locoregional recurrence, event and death and pRb predicted event and death. Within the HPV-positive group, after adjusting for clinicopathological factors, patients with cyclin D1-positive cancers had up to a eightfold increased risk of poor outcome relative to those with cyclin D1-negative tumors. However, within the HPV-negative group, there was only a very small adjusted increased risk. A combination of pRb and HPV did not provide additional prognostic information. Our data provide the first evidence that a combination of HPV and cyclin D1 provides more prognostic information in oropharyngeal cancer than HPV alone. If findings are confirmed, treatment based on HPV and cyclin D1 may improve outcomes. Copyright © 2010 UICC.

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http://hdl.handle.net/10453/117462