Periconceptional multivitamin use and risk of preterm or small-for-gestational-age Births in the Danish National birth cohort

Catov, JM; Bodnar, LM; Olsen, J; Olsen, S; Nohr, EA

Periconceptional multivitamin use and risk of preterm or small-for-gestational-age Births in the Danish National birth cohort

Catov, JM Bodnar, LM Olsen, J Olsen, S Nohr, EA

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Publication Type:: Journal Article
Citation:: American Journal of Clinical Nutrition, 2011, 94 (3), pp. 906 - 912
Issue Date:: 2011-09-01

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Field	Value	Language
dc.contributor.author	Catov, JM	en_US
dc.contributor.author	Bodnar, LM	en_US
dc.contributor.author	Olsen, J	en_US
dc.contributor.author	Olsen, S	en_US
dc.contributor.author	Nohr, EA	en_US
dc.date.issued	2011-09-01	en_US
dc.identifier.citation	American Journal of Clinical Nutrition, 2011, 94 (3), pp. 906 - 912	en_US
dc.identifier.issn	0002-9165	en_US
dc.identifier.uri	http://hdl.handle.net/10453/117471
dc.description.abstract	Background: The intake of periconceptional multivitamins may decrease the risk of preterm births (PTBs) or small-for-gestational-age (SGA) births. Objective: We related the timing and frequency of periconceptional multivitamin use to SGA births and PTBs and its clinical presentations (ie, preterm labor, premature rupture of membranes, and medical induction). Design: Women in the Danish National Birth Cohort (n = 35,897) reported the number of weeks of multivitamin use during a 12-wk periconceptional period. Cox regression was used to estimate the relation between any multivitamin use and PTBs (<37 wk) or SGA births (birth weight adjusted for gestational age >2 SDs below the mean on the basis of fetal growth curves). The timing (preconception and postconception) and frequency of use were also analyzed. Regular users (4-6 wk) and partial users (1-3 wk) in each period were compared with nonusers. Results: The association between periconceptional multivitamin use and PTBs varied according to prepregnancy overweight status (P-interaction = 0.07). Regular preconception and postconception multivitamin use in women with a prepregnancy BMI (in kg/m 2) <25 was associated with reduced risks of a PTB (HR: 0.84; 95% CI: 0.73, 0.95) and preterm labor (HR: 0.80; 95% CI: 0.69, 0.94). No similar associations were shown for overweight women. The adjusted risk of an SGA birth was reduced in multivitamin users regardless of their prepregnancy BMI (HR: 0.83; 95% CI: 0.73, 0.95), with the strongest association in regular users in the postconception period. Conclusion: Regular periconceptional multivitamin use was associated with reduced risk of SGA births and PTBs in nonoverweight women. © 2011 American Society for Nutrition.	en_US
dc.relation.ispartof	American Journal of Clinical Nutrition	en_US
dc.relation.isbasedon	10.3945/ajcn.111.012393	en_US
dc.subject.classification	Nutrition & Dietetics	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Pregnancy Complications	en_US
dc.subject.mesh	Premature Birth	en_US
dc.subject.mesh	Birth Weight	en_US
dc.subject.mesh	Vitamins	en_US
dc.subject.mesh	Proportional Hazards Models	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Cohort Studies	en_US
dc.subject.mesh	Fetal Development	en_US
dc.subject.mesh	Gestational Age	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Infant, Newborn	en_US
dc.subject.mesh	Infant, Small for Gestational Age	en_US
dc.subject.mesh	Infant, Premature	en_US
dc.subject.mesh	Denmark	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Overweight	en_US
dc.subject.mesh	Maternal Nutritional Physiological Phenomena	en_US
dc.subject.mesh	Young Adult	en_US
dc.title	Periconceptional multivitamin use and risk of preterm or small-for-gestational-age Births in the Danish National birth cohort	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	94	en_US
utslib.for	111402 Obstetrics and Gynaecology	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	09 Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	94	en_US

Abstract:

Background: The intake of periconceptional multivitamins may decrease the risk of preterm births (PTBs) or small-for-gestational-age (SGA) births. Objective: We related the timing and frequency of periconceptional multivitamin use to SGA births and PTBs and its clinical presentations (ie, preterm labor, premature rupture of membranes, and medical induction). Design: Women in the Danish National Birth Cohort (n = 35,897) reported the number of weeks of multivitamin use during a 12-wk periconceptional period. Cox regression was used to estimate the relation between any multivitamin use and PTBs (<37 wk) or SGA births (birth weight adjusted for gestational age >2 SDs below the mean on the basis of fetal growth curves). The timing (preconception and postconception) and frequency of use were also analyzed. Regular users (4-6 wk) and partial users (1-3 wk) in each period were compared with nonusers. Results: The association between periconceptional multivitamin use and PTBs varied according to prepregnancy overweight status (P-interaction = 0.07). Regular preconception and postconception multivitamin use in women with a prepregnancy BMI (in kg/m 2) <25 was associated with reduced risks of a PTB (HR: 0.84; 95% CI: 0.73, 0.95) and preterm labor (HR: 0.80; 95% CI: 0.69, 0.94). No similar associations were shown for overweight women. The adjusted risk of an SGA birth was reduced in multivitamin users regardless of their prepregnancy BMI (HR: 0.83; 95% CI: 0.73, 0.95), with the strongest association in regular users in the postconception period. Conclusion: Regular periconceptional multivitamin use was associated with reduced risk of SGA births and PTBs in nonoverweight women. © 2011 American Society for Nutrition.

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http://hdl.handle.net/10453/117471