Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: A study within the Danish National Birth Cohort

Harpsøe, MC; Basit, S; Bager, P; Wohlfahrt, J; Benn, CS; Nøhr, EA; Linneberg, A; Jess, T

Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: A study within the Danish National Birth Cohort

Harpsøe, MC Basit, S Bager, P Wohlfahrt, J Benn, CS Nøhr, EA Linneberg, A Jess, T

Permalink

Publication Type:: Journal Article
Citation:: Journal of Allergy and Clinical Immunology, 2013, 131 (4), pp. 1033 - 1040
Issue Date:: 2013-04-01

Closed Access

	Filename	Description	Size
	1-s2.0-S0091674912015023-main.pdf	Published Version	132.45 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Harpsøe, MC	en_US
dc.contributor.author	Basit, S	en_US
dc.contributor.author	Bager, P	en_US
dc.contributor.author	Wohlfahrt, J	en_US
dc.contributor.author	Benn, CS	en_US
dc.contributor.author	Nøhr, EA	en_US
dc.contributor.author	Linneberg, A	en_US
dc.contributor.author	Jess, T	en_US
dc.date.available	2012-09-13	en_US
dc.date.issued	2013-04-01	en_US
dc.identifier.citation	Journal of Allergy and Clinical Immunology, 2013, 131 (4), pp. 1033 - 1040	en_US
dc.identifier.issn	0091-6749	en_US
dc.identifier.uri	http://hdl.handle.net/10453/117646
dc.description.abstract	Background: High pre-pregnancy body mass index (BMI) and excessive gestational weight gain (GWG) are suggested to influence risk of asthma and atopic disease in offspring. Objective: We examined the effect of BMI and GWG on risk of asthma, wheezing, atopic eczema (AE), and hay fever in children during the first 7 years of life. Methods: This was a cohort study of 38,874 mother-child pairs from the Danish National Birth Cohort (enrollment 1996-2002) with information from the 16th week of pregnancy and at age 6 months, 18 months, and 7 years of the child. Odds ratios (ORs) with 95% CIs were calculated by logistic regression with adjustment for potential confounders. Results: During the first 7 years of life, 10.4% of children developed doctor-diagnosed asthma, 25.8% AE, and 4.6% hay fever. Maternal BMI and to a lesser extent GWG were associated with doctor-diagnosed asthma ever. In particular, BMI ≥ 35 (adjusted OR, 1.87; 95% CI, 0.95-3.68) and GWG ≥ 25 kg (adjusted OR, 1.97; 95% CI, 1.38-2.83) were associated with current severe asthma at age 7 years. Maternal BMI was also associated with wheezing in offspring, with the strongest association observed between BMI ≥ 35 and late-onset wheezing (adjusted OR, 1.87; 95% CI, 1.28-2.73). Maternal BMI and GWG were not associated with AE or hay fever. Conclusions: Maternal obesity during pregnancy was associated with increased risk of asthma and wheezing in offspring but not with AE and hay fever, suggesting that pathways may be nonallergic. © 2013 American Academy of Allergy, Asthma & Immunology.	en_US
dc.relation.ispartof	Journal of Allergy and Clinical Immunology	en_US
dc.relation.isbasedon	10.1016/j.jaci.2012.09.008	en_US
dc.subject.classification	Allergy	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Asthma	en_US
dc.subject.mesh	Dermatitis, Atopic	en_US
dc.subject.mesh	Obesity	en_US
dc.subject.mesh	Birth Weight	en_US
dc.subject.mesh	Weight Gain	en_US
dc.subject.mesh	Respiratory Sounds	en_US
dc.subject.mesh	Body Mass Index	en_US
dc.subject.mesh	Logistic Models	en_US
dc.subject.mesh	Odds Ratio	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Cohort Studies	en_US
dc.subject.mesh	Gestational Age	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Child	en_US
dc.subject.mesh	Child, Preschool	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Rhinitis, Allergic, Seasonal	en_US
dc.subject.mesh	Male	en_US
dc.title	Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: A study within the Danish National Birth Cohort	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	131	en_US
utslib.for	1107 Immunology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	131	en_US

Abstract:

Background: High pre-pregnancy body mass index (BMI) and excessive gestational weight gain (GWG) are suggested to influence risk of asthma and atopic disease in offspring. Objective: We examined the effect of BMI and GWG on risk of asthma, wheezing, atopic eczema (AE), and hay fever in children during the first 7 years of life. Methods: This was a cohort study of 38,874 mother-child pairs from the Danish National Birth Cohort (enrollment 1996-2002) with information from the 16th week of pregnancy and at age 6 months, 18 months, and 7 years of the child. Odds ratios (ORs) with 95% CIs were calculated by logistic regression with adjustment for potential confounders. Results: During the first 7 years of life, 10.4% of children developed doctor-diagnosed asthma, 25.8% AE, and 4.6% hay fever. Maternal BMI and to a lesser extent GWG were associated with doctor-diagnosed asthma ever. In particular, BMI ≥ 35 (adjusted OR, 1.87; 95% CI, 0.95-3.68) and GWG ≥ 25 kg (adjusted OR, 1.97; 95% CI, 1.38-2.83) were associated with current severe asthma at age 7 years. Maternal BMI was also associated with wheezing in offspring, with the strongest association observed between BMI ≥ 35 and late-onset wheezing (adjusted OR, 1.87; 95% CI, 1.28-2.73). Maternal BMI and GWG were not associated with AE or hay fever. Conclusions: Maternal obesity during pregnancy was associated with increased risk of asthma and wheezing in offspring but not with AE and hay fever, suggesting that pathways may be nonallergic. © 2013 American Academy of Allergy, Asthma & Immunology.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/117646