Incidence and severity of self-reported chemotherapy side effects in routine care: A prospective cohort study

Pearce, A; Haas, M; Viney, R; Pearson, SA; Haywood, P; Brown, C; Ward, R

Incidence and severity of self-reported chemotherapy side effects in routine care: A prospective cohort study

Pearce, A

Haas, M

Viney, R

Pearson, SA Haywood, P

Brown, C Ward, R

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Publication Type:: Journal Article
Citation:: PLoS ONE, 2017, 12 (10)
Issue Date:: 2017-10-01

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Field	Value	Language
dc.contributor.author	Pearce, A https://orcid.org/0000-0002-5690-9542	en_US
dc.contributor.author	Haas, M https://orcid.org/0000-0002-9726-3063	en_US
dc.contributor.author	Viney, R https://orcid.org/0000-0002-0039-9635	en_US
dc.contributor.author	Pearson, SA	en_US
dc.contributor.author	Haywood, P https://orcid.org/0000-0001-5031-8648	en_US
dc.contributor.author	Brown, C	en_US
dc.contributor.author	Ward, R	en_US
dc.date.available	2017-08-22	en_US
dc.date.issued	2017-10-01	en_US
dc.identifier.citation	PLoS ONE, 2017, 12 (10)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/121205
dc.description.abstract	© 2017 Pearce et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Aim: Chemotherapy side effects are often reported in clinical trials; however, there is little evidence about their incidence in routine clinical care. The objective of this study was to describe the frequency and severity of patient-reported chemotherapy side effects in routine care across treatment centres in Australia. Methods: We conducted a prospective cohort study of individuals with breast, lung or colorectal cancer undergoing chemotherapy. Side effects were identified by patient self-report. The frequency, prevalence and incidence rates of side effects were calculated by cancer type and grade, and cumulative incidence curves for each side effect computed. Frequencies of side effects were compared between demographic subgroups using chi-squared statistics. Results: Side effect data were available for 449 eligible individuals, who had a median follow-up of 5.64 months. 86% of participants reported at least one side effect during the study period and 27% reported a grade IV side effect, most commonly fatigue or dyspnoea. Fatigue was the most common side effect overall (85%), followed by diarrhoea (74%) and constipation (74%). Prevalence and incidence rates were similar across side effects and cancer types. Age was the only demographic factor associated with the incidence of side effects, with older people less likely to report side effects. Conclusion: This research has produced the first Australian estimates of self-reported incidence of chemotherapy side effects in routine clinical care. Chemotherapy side effects in routine care are common, continue throughout chemotherapy and can be serious. This work confirms the importance of observational data in providing clinical practice-relevant information to decision-makers.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/455366
dc.relation.ispartof	PLoS ONE	en_US
dc.relation.isbasedon	10.1371/journal.pone.0184360	en_US
dc.subject.classification	General Science & Technology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Breast Neoplasms	en_US
dc.subject.mesh	Colorectal Neoplasms	en_US
dc.subject.mesh	Lung Neoplasms	en_US
dc.subject.mesh	Neoplasm Staging	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Self Report	en_US
dc.subject.mesh	Drug-Related Side Effects and Adverse Reactions	en_US
dc.subject.mesh	Surveys and Questionnaires	en_US
dc.title	Incidence and severity of self-reported chemotherapy side effects in routine care: A prospective cohort study	en_US
dc.type	Journal Article
utslib.citation.volume	10	en_US
utslib.citation.volume	12	en_US
utslib.for	111205 Chemotherapy	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Business
pubs.organisational-group	/University of Technology Sydney/Strength - CHERE - Centre for Health Economics Research and Evaluation
utslib.copyright.status	open_access
dcterms.license	This work is distributed under a Creative Commons Attribution license (CC BY) http://creativecommons.org/licenses/by/4.0/
pubs.issue	10	en_US
pubs.publication-status	Published	en_US
pubs.volume	12	en_US

Abstract:

© 2017 Pearce et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Aim: Chemotherapy side effects are often reported in clinical trials; however, there is little evidence about their incidence in routine clinical care. The objective of this study was to describe the frequency and severity of patient-reported chemotherapy side effects in routine care across treatment centres in Australia. Methods: We conducted a prospective cohort study of individuals with breast, lung or colorectal cancer undergoing chemotherapy. Side effects were identified by patient self-report. The frequency, prevalence and incidence rates of side effects were calculated by cancer type and grade, and cumulative incidence curves for each side effect computed. Frequencies of side effects were compared between demographic subgroups using chi-squared statistics. Results: Side effect data were available for 449 eligible individuals, who had a median follow-up of 5.64 months. 86% of participants reported at least one side effect during the study period and 27% reported a grade IV side effect, most commonly fatigue or dyspnoea. Fatigue was the most common side effect overall (85%), followed by diarrhoea (74%) and constipation (74%). Prevalence and incidence rates were similar across side effects and cancer types. Age was the only demographic factor associated with the incidence of side effects, with older people less likely to report side effects. Conclusion: This research has produced the first Australian estimates of self-reported incidence of chemotherapy side effects in routine clinical care. Chemotherapy side effects in routine care are common, continue throughout chemotherapy and can be serious. This work confirms the importance of observational data in providing clinical practice-relevant information to decision-makers.

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http://hdl.handle.net/10453/121205