Azachalcones: A new class of potent polyphenol oxidase inhibitors

Radhakrishnan, SK; Shimmon, RG; Conn, C; Baker, AT

Azachalcones: A new class of potent polyphenol oxidase inhibitors

Radhakrishnan, SK Shimmon, RG

Conn, C Baker, AT

Permalink

Publication Type:: Journal Article
Citation:: Bioorganic and Medicinal Chemistry Letters, 2015, 25 (8), pp. 1753 - 1756
Issue Date:: 2015-04-15

Closed Access

	Filename	Description	Size
	Azachalcones A new class of potent polyphenol oxidase inhibitors.pdf	Published Version	688.59 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Radhakrishnan, SK	en_US
dc.contributor.author	Shimmon, RG https://orcid.org/0000-0002-8763-991X	en_US
dc.contributor.author	Conn, C	en_US
dc.contributor.author	Baker, AT https://orcid.org/0000-0001-9700-0178	en_US
dc.date.available	2015-02-23	en_US
dc.date.issued	2015-04-15	en_US
dc.identifier.citation	Bioorganic and Medicinal Chemistry Letters, 2015, 25 (8), pp. 1753 - 1756	en_US
dc.identifier.issn	0960-894X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122538
dc.description.abstract	© 2015 Elsevier Ltd.All rights reserved. A library of potent inhibitors of polyphenol oxidase and their structure activity relationships are described. Azachalcone derivatives were synthesized and tested for their tyrosinase inhibitory activity. Their inhibitory activities on mushroom tyrosinase using l-DOPA as a substrate were investigated. Two compounds that are the reduction congeners of the pyridinyl azachalcones strongly inhibited the enzyme activity and were more potent than the positive control kojic acid.	en_US
dc.relation.ispartof	Bioorganic and Medicinal Chemistry Letters	en_US
dc.relation.isbasedon	10.1016/j.bmcl.2015.02.060	en_US
dc.subject.classification	Medicinal & Biomolecular Chemistry	en_US
dc.subject.mesh	Agaricales	en_US
dc.subject.mesh	Levodopa	en_US
dc.subject.mesh	Aza Compounds	en_US
dc.subject.mesh	Chalcones	en_US
dc.subject.mesh	Catechol Oxidase	en_US
dc.subject.mesh	Monophenol Monooxygenase	en_US
dc.subject.mesh	Enzyme Inhibitors	en_US
dc.subject.mesh	Protein Binding	en_US
dc.subject.mesh	Structure-Activity Relationship	en_US
dc.subject.mesh	Kinetics	en_US
dc.title	Azachalcones: A new class of potent polyphenol oxidase inhibitors	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	25	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	0305 Organic Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Business
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Chemistry and Forensic Science
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	closed_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	25	en_US

Abstract:

© 2015 Elsevier Ltd.All rights reserved. A library of potent inhibitors of polyphenol oxidase and their structure activity relationships are described. Azachalcone derivatives were synthesized and tested for their tyrosinase inhibitory activity. Their inhibitory activities on mushroom tyrosinase using l-DOPA as a substrate were investigated. Two compounds that are the reduction congeners of the pyridinyl azachalcones strongly inhibited the enzyme activity and were more potent than the positive control kojic acid.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/122538