Faculty of Science

Most Recent
Most Downloaded

Identification of genes influencing the evolution of Escherichia coli ST372 in dogs and humans.

Elankumuran, P Browning, GF Marenda, MS Kidsley, A Osman, M Haenni, M Johnson, JR Trott, DJ Reid, CJ Djordjevic, SP

ST372 are widely reported as the major Escherichia coli sequence type in dogs globally. They are also a sporadic cause of extraintestinal infections in humans. Despite this, it is unknown whether S...

Continue Reading
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.

Mu, A Klare, WP Baines, SL Ignatius Pang, CN Guérillot, R Harbison-Price, N Keller, N Wilksch, J Nhu, NTK Phan, M-D Keller, B Nijagal, B Tull, D Dayalan, S Chua, HHC Skoneczny, D Koval, J Hachani, A Shah, AD Neha, N Jadhav, S Partridge, SR Cork, AJ Peters, K Bertolla, O Brouwer, S Hancock, SJ Álvarez-Fraga, L De Oliveira, DMP Forde, B Dale, A Mujchariyakul, W Walsh, CJ Monk, I Fitzgerald, A Lum, M Correa-Ospina, C Roy Chowdhury, P Parton, RG De Voss, J Beckett, J Monty, F McKinnon, J Song, X Stephen, JR Everest, M Bellgard, MI Tinning, M Leeming, M Hocking, D Jebeli, L Wang, N Ben Zakour, N Yasar, SA Vecchiarelli, S Russell, T Zaw, T Chen, T Teng, D Kassir, Z Lithgow, T Jenney, A Cole, JN Nizet, V Sorrell, TC Peleg, AY Paterson, DL Beatson, SA Wu, J Molloy, MP Syme, AE Goode, RJA Hunter, AA Bowland, G West, NP Wilkins, MR Djordjevic, SP Davies, MR Seemann, T Howden, BP Pascovici, D Tyagi, S Schittenhelm, RB De Souza, DP McConville, MJ Iredell, JR Cordwell, SJ Strugnell, RA Stinear, TP Schembri, MA Walker, MJ

Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality ri...

Continue Reading
Phylogenetic Analysis of Escherichia coli Isolated from Australian Feedlot Cattle in Comparison to Pig Faecal and Poultry/Human Extraintestinal Isolates.

Messele, YE Trott, DJ Hasoon, MF Veltman, T McMeniman, JP Kidd, SP Djordjevic, SP Petrovski, KR Low, WY

The similarity of commensal Escherichia coli isolated from healthy cattle to antimicrobial-resistant bacteria causing extraintestinal infections in humans is not fully understood. In this study, we...

Continue Reading
Whole Genome Sequencing of Avian Pathogenic Escherichia coli Causing Bacterial Chondronecrosis and Osteomyelitis in Australian Poultry.

Cummins, ML Li, D Ahmad, A Bushell, R Noormohammadi, AH Wijesurendra, DS Stent, A Marenda, MS Djordjevic, SP

Bacterial chondronecrosis with osteomyelitis (BCO) impacts animal welfare and productivity in the poultry industry worldwide, yet it has an understudied pathogenesis. While Avian Pathogenic Escheri...

Continue Reading
Dominance of Escherichia coli sequence types ST73, ST95, ST127 and ST131 in Australian urine isolates: a genomic analysis of antimicrobial resistance and virulence linked to F plasmids.

Li, D Elankumaran, P Kudinha, T Kidsley, AK Trott, DJ Jarocki, VM Djordjevic, SP

Extraintestinal pathogenic Escherichia coli (ExPEC) are the most frequent cause of urinary tract infections (UTIs) globally. Most studies of clinical E. coli isolates are selected based on their an...

Continue Reading
Expanding the range of the respiratory infectome in Australian feedlot cattle with and without respiratory disease using metatranscriptomics.

Brito, BP Frost, MJ Anantanawat, K Jaya, F Batterham, T Djordjevic, SP Chang, W-S Holmes, EC Darling, AE Kirkland, PD

BACKGROUND: Bovine respiratory disease (BRD) is one of the most common diseases in intensively managed cattle, often resulting in high morbidity and mortality. Although several pathogens have been ...

Continue Reading
Phylogenomic analysis of a global collection of Escherichia coli ST38: evidence of interspecies and environmental transmission?

Roy Chowdhury, P Hastak, P DeMaere, M Wyrsch, E Li, D Elankumaran, P Dolejska, M Browning, GF Marenda, MS Gottlieb, T Cheong, E Merlino, J Myers, GSA Djordjevic, SP

We performed a comprehensive phylogenomic analysis of 925 extraintestinal pathogenic Escherichia coli (ExPEC) ST38 genomes from 38 countries and diverse hosts and sources. The phylogeny resolved tw...

Continue Reading
Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls.

Kruk, D Yeung, ACY Faiz, A Ten Hacken, NHT Timens, W van Kuppevelt, TH Daamen, W Hof, D Harmsen, MC Rojas, M Heijink, IH

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal c...

Continue Reading
Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms.

Kole, TM Pouwels, SD Bults, R Ketelaar, ME Guryev, V Koll, L Kerstjens, HAM Nawijn, MC Faiz, A van den Berge, M

Studying the effects of asthma SNPs on alternative splicing can lead to new insights into asthma pathophysiology. More specifically, a 17q12 SNP is associated to alternative splicing of GSDMB. http...

Continue Reading
Impact of changes in human airway epithelial cellular composition and differentiation on SARS-CoV-2 infection biology.

Thaler, M Wang, Y van der Does, AM Faiz, A Ninaber, DK Ogando, NS Beckert, H Taube, C Salgado-Benvindo, C Snijder, EJ Bredenbeek, PJ Hiemstra, PS van Hemert, MJ

The consequences of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can range from asymptomatic to fatal disease. Variations in epithelial susceptibility to SARS-CoV-2 i...

Continue Reading