One evidence base; three stories: do opioids relieve chronic breathlessness?

Ekström, M; Bajwah, S; Bland, JM; Currow, DC; Hussain, J; Johnson, MJ

One evidence base; three stories: do opioids relieve chronic breathlessness?

Ekström, M Bajwah, S Bland, JM Currow, DC

Hussain, J Johnson, MJ

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Publication Type:: Journal Article
Citation:: Thorax, 2018, 73 (1), pp. 88 - 90
Issue Date:: 2018-01-01

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Field	Value	Language
dc.contributor.author	Ekström, M	en_US
dc.contributor.author	Bajwah, S	en_US
dc.contributor.author	Bland, JM	en_US
dc.contributor.author	Currow, DC https://orcid.org/0000-0003-1988-1250	en_US
dc.contributor.author	Hussain, J	en_US
dc.contributor.author	Johnson, MJ	en_US
dc.date.available	2017-03-10	en_US
dc.date.issued	2018-01-01	en_US
dc.identifier.citation	Thorax, 2018, 73 (1), pp. 88 - 90	en_US
dc.identifier.uri	http://hdl.handle.net/10453/123599
dc.description.abstract	Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/. The efficacy of low-dose systemic opioids for chronic breathlessness was questioned by the recent Cochrane review by Barnes et al We examined the reasons for this conflicting finding and re-evaluated the efficacy of systemic opioids. Compared with previous meta-analyses, Barnes et al reported a smaller effect and lower precision, but did not account for matched data of crossover trials (11/12 included trials) and added a risk-of-bias criterion (sample size). When re-analysed to account for crossover data, opioids decreased breathlessness (standardised mean differences -0.32; -0.18 to -0.47; I2=44.8%) representing a clinically meaningful reduction of 0.8 points (0-10 numerical rating scale), consistent across meta-analyses.	en_US
dc.relation.ispartof	Thorax	en_US
dc.relation.isbasedon	10.1136/thoraxjnl-2016-209868	en_US
dc.subject.classification	Respiratory System	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Dyspnea	en_US
dc.subject.mesh	Chronic Disease	en_US
dc.subject.mesh	Analgesics, Opioid	en_US
dc.title	One evidence base; three stories: do opioids relieve chronic breathlessness?	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	73	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/IMPACCT
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	73	en_US

Abstract:

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/. The efficacy of low-dose systemic opioids for chronic breathlessness was questioned by the recent Cochrane review by Barnes et al We examined the reasons for this conflicting finding and re-evaluated the efficacy of systemic opioids. Compared with previous meta-analyses, Barnes et al reported a smaller effect and lower precision, but did not account for matched data of crossover trials (11/12 included trials) and added a risk-of-bias criterion (sample size). When re-analysed to account for crossover data, opioids decreased breathlessness (standardised mean differences -0.32; -0.18 to -0.47; I2=44.8%) representing a clinically meaningful reduction of 0.8 points (0-10 numerical rating scale), consistent across meta-analyses.

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http://hdl.handle.net/10453/123599