Patterns of antimicrobial resistance in intensive care unit patients: A study in Vietnam

Tran, GM; Ho-Le, TP; Ha, DT; Tran-Nguyen, CH; Nguyen, TSM; Pham, TTN; Nguyen, TA; Nguyen, DA; Hoang, HQ; Tran, NV; Nguyen, TV

Patterns of antimicrobial resistance in intensive care unit patients: A study in Vietnam

Tran, GM Ho-Le, TP Ha, DT Tran-Nguyen, CH Nguyen, TSM Pham, TTN Nguyen, TA Nguyen, DA Hoang, HQ Tran, NV Nguyen, TV

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Publication Type:: Journal Article
Citation:: BMC Infectious Diseases, 2017, 17 (1)
Issue Date:: 2017-01-01

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Field	Value	Language
dc.contributor.author	Tran, GM	en_US
dc.contributor.author	Ho-Le, TP	en_US
dc.contributor.author	Ha, DT	en_US
dc.contributor.author	Tran-Nguyen, CH	en_US
dc.contributor.author	Nguyen, TSM	en_US
dc.contributor.author	Pham, TTN	en_US
dc.contributor.author	Nguyen, TA	en_US
dc.contributor.author	Nguyen, DA	en_US
dc.contributor.author	Hoang, HQ	en_US
dc.contributor.author	Tran, NV	en_US
dc.contributor.author	Nguyen, TV https://orcid.org/0000-0002-3246-6281	en_US
dc.date.available	2017-06-06	en_US
dc.date.issued	2017-01-01	en_US
dc.identifier.citation	BMC Infectious Diseases, 2017, 17 (1)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/125373
dc.description.abstract	© The Author(s). 2017. Background: Antimicrobial resistance has emerged as a major concern in developing countries. The present study sought to define the pattern of antimicrobial resistance in ICU patients with ventilator-associated pneumonia. Methods: Between November 2014 and September 2015, we enrolled 220 patients (average age ~ 71 yr) who were admitted to ICU in a major tertiary hospital in Ho Chi Minh City, Vietnam. Data concerning demographic characteristics and clinical history were collected from each patient. The Bauer-Kirby disk diffusion method was used to detect the antimicrobial susceptibility. Results: Antimicrobial resistance was commonly found in ceftriaxone (88%), ceftazidime (80%), ciprofloxacin (77%), cefepime (75%), levofloxacin (72%). Overall, the rate of antimicrobial resistance to any drug was 93% (n = 153/164), with the majority (87%) being resistant to at least 2 drugs. The three commonly isolated microorganisms were Acinetobacter (n = 75), Klebsiella (n = 39), and Pseudomonas aeruginosa (n = 29). Acinetobacter baumannii were virtually resistant to ceftazidime, ceftriaxone, piperacilin, imipenem, meropenem, ertapenem, ciprofloxacin and levofloxacin. High rates ( > 70%) of ceftriaxone and ceftazidime-resistant Klebsiella were also observed. Conclusion: These data indicated that critically ill patients on ventilator in Vietnam were at disturbingly high risk of antimicrobial resistance. The data also imply that these Acinetobacter, Klebsiella, and Pseudomonas aeruginosa and multidrug resistance pose serious therapeutic problems in ICU patients. A concerted and systematic effort is required to rapidly identify high risk patients and to reduce the burden of antimicrobial resistance in developing countries.	en_US
dc.relation.ispartof	BMC Infectious Diseases	en_US
dc.relation.isbasedon	10.1186/s12879-017-2529-z	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Acinetobacter baumannii	en_US
dc.subject.mesh	Pseudomonas aeruginosa	en_US
dc.subject.mesh	Klebsiella	en_US
dc.subject.mesh	Acinetobacter Infections	en_US
dc.subject.mesh	Pseudomonas Infections	en_US
dc.subject.mesh	beta-Lactams	en_US
dc.subject.mesh	Imipenem	en_US
dc.subject.mesh	Ceftazidime	en_US
dc.subject.mesh	Ciprofloxacin	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Microbial Sensitivity Tests	en_US
dc.subject.mesh	Drug Resistance, Bacterial	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Intensive Care Units	en_US
dc.subject.mesh	Vietnam	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Pneumonia, Ventilator-Associated	en_US
dc.subject.mesh	Ertapenem	en_US
dc.title	Patterns of antimicrobial resistance in intensive care unit patients: A study in Vietnam	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	17	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access	*
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	17	en_US

Abstract:

© The Author(s). 2017. Background: Antimicrobial resistance has emerged as a major concern in developing countries. The present study sought to define the pattern of antimicrobial resistance in ICU patients with ventilator-associated pneumonia. Methods: Between November 2014 and September 2015, we enrolled 220 patients (average age ~ 71 yr) who were admitted to ICU in a major tertiary hospital in Ho Chi Minh City, Vietnam. Data concerning demographic characteristics and clinical history were collected from each patient. The Bauer-Kirby disk diffusion method was used to detect the antimicrobial susceptibility. Results: Antimicrobial resistance was commonly found in ceftriaxone (88%), ceftazidime (80%), ciprofloxacin (77%), cefepime (75%), levofloxacin (72%). Overall, the rate of antimicrobial resistance to any drug was 93% (n = 153/164), with the majority (87%) being resistant to at least 2 drugs. The three commonly isolated microorganisms were Acinetobacter (n = 75), Klebsiella (n = 39), and Pseudomonas aeruginosa (n = 29). Acinetobacter baumannii were virtually resistant to ceftazidime, ceftriaxone, piperacilin, imipenem, meropenem, ertapenem, ciprofloxacin and levofloxacin. High rates ( > 70%) of ceftriaxone and ceftazidime-resistant Klebsiella were also observed. Conclusion: These data indicated that critically ill patients on ventilator in Vietnam were at disturbingly high risk of antimicrobial resistance. The data also imply that these Acinetobacter, Klebsiella, and Pseudomonas aeruginosa and multidrug resistance pose serious therapeutic problems in ICU patients. A concerted and systematic effort is required to rapidly identify high risk patients and to reduce the burden of antimicrobial resistance in developing countries.

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http://hdl.handle.net/10453/125373