The use of a risk assessment and decision support tool (CRISP) compared with usual care in general practice to increase risk-stratified colorectal cancer screening: Study protocol for a randomised controlled trial

Walker, JG; Macrae, F; Winship, I; Oberoi, J; Saya, S; Milton, S; Bickerstaffe, A; Dowty, JG; De Abreu Lourenço, R; Clark, M; Galloway, L; Fishman, G; Walter, FM; Flander, L; Chondros, P; Ait Ouakrim, D; Pirotta, M; Trevena, L; Jenkins, MA; Emery, JD

The use of a risk assessment and decision support tool (CRISP) compared with usual care in general practice to increase risk-stratified colorectal cancer screening: Study protocol for a randomised controlled trial

Macrae, F Winship, I Oberoi, J Saya, S Milton, S Bickerstaffe, A Dowty, JG De Abreu Lourenço, R

Clark, M Galloway, L Fishman, G Walter, FM Flander, L Chondros, P Ait Ouakrim, D Pirotta, M Trevena, L Jenkins, MA Emery, JD

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Publication Type:: Journal Article
Citation:: Trials, 2018, 19 (1)
Issue Date:: 2018-07-25

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Field	Value	Language
dc.contributor.author	Walker, JG https://orcid.org/0000-0002-6655-0940	en_US
dc.contributor.author	Macrae, F	en_US
dc.contributor.author	Winship, I	en_US
dc.contributor.author	Oberoi, J	en_US
dc.contributor.author	Saya, S	en_US
dc.contributor.author	Milton, S	en_US
dc.contributor.author	Bickerstaffe, A	en_US
dc.contributor.author	Dowty, JG	en_US
dc.contributor.author	De Abreu Lourenço, R https://orcid.org/0000-0002-5978-8774	en_US
dc.contributor.author	Clark, M	en_US
dc.contributor.author	Galloway, L	en_US
dc.contributor.author	Fishman, G	en_US
dc.contributor.author	Walter, FM	en_US
dc.contributor.author	Flander, L	en_US
dc.contributor.author	Chondros, P	en_US
dc.contributor.author	Ait Ouakrim, D	en_US
dc.contributor.author	Pirotta, M	en_US
dc.contributor.author	Trevena, L	en_US
dc.contributor.author	Jenkins, MA	en_US
dc.contributor.author	Emery, JD	en_US
dc.date.available	2018-06-25	en_US
dc.date.issued	2018-07-25	en_US
dc.identifier.citation	Trials, 2018, 19 (1)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126601
dc.description.abstract	© 2018 The Author(s). Background: Australia and New Zealand have the highest incidence rates of colorectal cancer worldwide. In Australia there is significant unwarranted variation in colorectal cancer screening due to low uptake of the immunochemical faecal occult blood test, poor identification of individuals at increased risk of colorectal cancer, and over-referral of individuals at average risk for colonoscopy. Our pre-trial research has developed a novel Colorectal cancer RISk Prediction (CRISP) tool, which could be used to implement precision screening in primary care. This paper describes the protocol for a phase II multi-site individually randomised controlled trial of the CRISP tool in primary care. Methods: This trial aims to test whether a standardised consultation using the CRISP tool in general practice (the CRISP intervention) increases risk-appropriate colorectal cancer screening compared to control participants who receive standardised information on cancer prevention. Patients between 50 and 74 years old, attending an appointment with their general practitioner for any reason, will be invited into the trial. A total of 732 participants will be randomised to intervention or control arms using a computer-generated allocation sequence stratified by general practice. The primary outcome (risk-appropriate screening at 12 months) will be measured using baseline data for colorectal cancer risk and objective health service data to measure screening behaviour. Secondary outcomes will include participant cancer risk perception, anxiety, cancer worry, screening intentions and health service utilisation measured at 1, 6 and 12 months post randomisation. Discussion: This trial tests a systematic approach to implementing risk-stratified colorectal cancer screening in primary care, based on an individual's absolute risk, using a state-of-the-art risk assessment tool.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1121104
dc.relation.ispartof	Trials	en_US
dc.relation.isbasedon	10.1186/s13063-018-2764-7	en_US
dc.subject.classification	General & Internal Medicine	en_US
dc.subject.classification	Cardiovascular System & Hematology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Colorectal Neoplasms	en_US
dc.subject.mesh	Prognosis	en_US
dc.subject.mesh	Risk Assessment	en_US
dc.subject.mesh	Risk Factors	en_US
dc.subject.mesh	Predictive Value of Tests	en_US
dc.subject.mesh	Decision Support Techniques	en_US
dc.subject.mesh	Time Factors	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Primary Health Care	en_US
dc.subject.mesh	Victoria	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Multicenter Studies as Topic	en_US
dc.subject.mesh	Randomized Controlled Trials as Topic	en_US
dc.subject.mesh	Clinical Trials, Phase II as Topic	en_US
dc.subject.mesh	Early Detection of Cancer	en_US
dc.subject.mesh	General Practice	en_US
dc.title	The use of a risk assessment and decision support tool (CRISP) compared with usual care in general practice to increase risk-stratified colorectal cancer screening: Study protocol for a randomised controlled trial	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	19	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1102 Cardiorespiratory Medicine and Haematology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Business
pubs.organisational-group	/University of Technology Sydney/Strength - CHERE - Centre for Health Economics Research and Evaluation
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	19	en_US

Abstract:

© 2018 The Author(s). Background: Australia and New Zealand have the highest incidence rates of colorectal cancer worldwide. In Australia there is significant unwarranted variation in colorectal cancer screening due to low uptake of the immunochemical faecal occult blood test, poor identification of individuals at increased risk of colorectal cancer, and over-referral of individuals at average risk for colonoscopy. Our pre-trial research has developed a novel Colorectal cancer RISk Prediction (CRISP) tool, which could be used to implement precision screening in primary care. This paper describes the protocol for a phase II multi-site individually randomised controlled trial of the CRISP tool in primary care. Methods: This trial aims to test whether a standardised consultation using the CRISP tool in general practice (the CRISP intervention) increases risk-appropriate colorectal cancer screening compared to control participants who receive standardised information on cancer prevention. Patients between 50 and 74 years old, attending an appointment with their general practitioner for any reason, will be invited into the trial. A total of 732 participants will be randomised to intervention or control arms using a computer-generated allocation sequence stratified by general practice. The primary outcome (risk-appropriate screening at 12 months) will be measured using baseline data for colorectal cancer risk and objective health service data to measure screening behaviour. Secondary outcomes will include participant cancer risk perception, anxiety, cancer worry, screening intentions and health service utilisation measured at 1, 6 and 12 months post randomisation. Discussion: This trial tests a systematic approach to implementing risk-stratified colorectal cancer screening in primary care, based on an individual's absolute risk, using a state-of-the-art risk assessment tool.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/126601