Frailty in patients with advanced heart failure referred for heart transplantation

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Frailty research within advanced heart failure (AHF) is a nascent concept. Frailty is defined as an increased vulnerability to stressors in response to an individual’s declining physiological reserve. As physiological reserves naturally decline with advancing age, frailty is considered a geriatric syndrome. While the significance of frailty is well entrenched within geriatric medicine, the impact of frailty among other specialties is only emerging. The increased survival of an ageing highly co-morbid populace of heart failure patients alongside the expanding use of invasive surgical interventions, has propelled frailty exploration into the forefront of cardiovascular research. This thesis by publication represents the first set of studies to explore the impact of frailty in patients with advanced heart failure referred for heart transplantation.
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