Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
Schumacher, FR
Al Olama, AA
Berndt, SI
Benlloch, S
Ahmed, M
Saunders, EJ
Dadaev, T
Leongamornlert, D
Anokian, E
Cieza-Borrella, C
Goh, C
Brook, MN
Sheng, X
Fachal, L
Dennis, J
Tyrer, J
Muir, K
Lophatananon, A
Stevens, VL
Gapstur, SM
Carter, BD
Tangen, CM
Goodman, PJ
Thompson, IM
Batra, J
Chambers, S
Moya, L
Clements, J
Horvath, L
Tilley, W
Risbridger, GP
Gronberg, H
Aly, M
Nordström, T
Pharoah, P
Pashayan, N
Schleutker, J
Tammela, TLJ
Sipeky, C
Auvinen, A
Albanes, D
Weinstein, S
Wolk, A
Håkansson, N
West, CML
Dunning, AM
Burnet, N
Mucci, LA
Giovannucci, E
Andriole, GL
Cussenot, O
Cancel-Tassin, G
Koutros, S
Beane Freeman, LE
Sorensen, KD
Orntoft, TF
Borre, M
Maehle, L
Grindedal, EM
Neal, DE
Donovan, JL
Hamdy, FC
Martin, RM
Travis, RC
Key, TJ
Hamilton, RJ
Fleshner, NE
Finelli, A
Ingles, SA
Stern, MC
Rosenstein, BS
Kerns, SL
Ostrer, H
Lu, YJ
Zhang, HW
Feng, N
Mao, X
Guo, X
Wang, G
Sun, Z
Giles, GG
Southey, MC
MacInnis, RJ
Fitzgerald, LM
Kibel, AS
Drake, BF
Vega, A
Gómez-Caamaño, A
Szulkin, R
Eklund, M
Kogevinas, M
Llorca, J
Castaño-Vinyals, G
Penney, KL
Stampfer, M
Park, JY
Sellers, TA
Lin, HY
Stanford, JL
Cybulski, C
- Publication Type:
- Journal Article
- Citation:
- Nature Genetics, 2018, 50 (7), pp. 928 - 936
- Issue Date:
- 2018-07-01
Closed Access
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s41588-018-0142-8.pdf | Published Version | 2.42 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Schumacher, FR | en_US |
dc.contributor.author | Al Olama, AA | en_US |
dc.contributor.author | Berndt, SI | en_US |
dc.contributor.author | Benlloch, S | en_US |
dc.contributor.author | Ahmed, M | en_US |
dc.contributor.author | Saunders, EJ | en_US |
dc.contributor.author | Dadaev, T | en_US |
dc.contributor.author | Leongamornlert, D | en_US |
dc.contributor.author | Anokian, E | en_US |
dc.contributor.author | Cieza-Borrella, C | en_US |
dc.contributor.author | Goh, C | en_US |
dc.contributor.author | Brook, MN | en_US |
dc.contributor.author | Sheng, X | en_US |
dc.contributor.author | Fachal, L | en_US |
dc.contributor.author | Dennis, J | en_US |
dc.contributor.author | Tyrer, J | en_US |
dc.contributor.author | Muir, K | en_US |
dc.contributor.author | Lophatananon, A | en_US |
dc.contributor.author | Stevens, VL | en_US |
dc.contributor.author | Gapstur, SM | en_US |
dc.contributor.author | Carter, BD | en_US |
dc.contributor.author | Tangen, CM | en_US |
dc.contributor.author | Goodman, PJ | en_US |
dc.contributor.author | Thompson, IM | en_US |
dc.contributor.author | Batra, J | en_US |
dc.contributor.author |
Chambers, S |
en_US |
dc.contributor.author | Moya, L | en_US |
dc.contributor.author | Clements, J | en_US |
dc.contributor.author | Horvath, L | en_US |
dc.contributor.author | Tilley, W | en_US |
dc.contributor.author | Risbridger, GP | en_US |
dc.contributor.author | Gronberg, H | en_US |
dc.contributor.author | Aly, M | en_US |
dc.contributor.author | Nordström, T | en_US |
dc.contributor.author | Pharoah, P | en_US |
dc.contributor.author | Pashayan, N | en_US |
dc.contributor.author | Schleutker, J | en_US |
dc.contributor.author | Tammela, TLJ | en_US |
dc.contributor.author | Sipeky, C | en_US |
dc.contributor.author | Auvinen, A | en_US |
dc.contributor.author | Albanes, D | en_US |
dc.contributor.author | Weinstein, S | en_US |
dc.contributor.author | Wolk, A | en_US |
dc.contributor.author | Håkansson, N | en_US |
dc.contributor.author | West, CML | en_US |
dc.contributor.author | Dunning, AM | en_US |
dc.contributor.author | Burnet, N | en_US |
dc.contributor.author | Mucci, LA | en_US |
dc.contributor.author | Giovannucci, E | en_US |
dc.contributor.author | Andriole, GL | en_US |
dc.contributor.author | Cussenot, O | en_US |
dc.contributor.author | Cancel-Tassin, G | en_US |
dc.contributor.author | Koutros, S | en_US |
dc.contributor.author | Beane Freeman, LE | en_US |
dc.contributor.author | Sorensen, KD | en_US |
dc.contributor.author | Orntoft, TF | en_US |
dc.contributor.author | Borre, M | en_US |
dc.contributor.author | Maehle, L | en_US |
dc.contributor.author | Grindedal, EM | en_US |
dc.contributor.author | Neal, DE | en_US |
dc.contributor.author | Donovan, JL | en_US |
dc.contributor.author | Hamdy, FC | en_US |
dc.contributor.author | Martin, RM | en_US |
dc.contributor.author | Travis, RC | en_US |
dc.contributor.author | Key, TJ | en_US |
dc.contributor.author | Hamilton, RJ | en_US |
dc.contributor.author | Fleshner, NE | en_US |
dc.contributor.author | Finelli, A | en_US |
dc.contributor.author | Ingles, SA | en_US |
dc.contributor.author | Stern, MC | en_US |
dc.contributor.author | Rosenstein, BS | en_US |
dc.contributor.author | Kerns, SL | en_US |
dc.contributor.author | Ostrer, H | en_US |
dc.contributor.author | Lu, YJ | en_US |
dc.contributor.author | Zhang, HW | en_US |
dc.contributor.author | Feng, N | en_US |
dc.contributor.author | Mao, X | en_US |
dc.contributor.author | Guo, X | en_US |
dc.contributor.author | Wang, G | en_US |
dc.contributor.author | Sun, Z | en_US |
dc.contributor.author | Giles, GG | en_US |
dc.contributor.author | Southey, MC | en_US |
dc.contributor.author | MacInnis, RJ | en_US |
dc.contributor.author | Fitzgerald, LM | en_US |
dc.contributor.author | Kibel, AS | en_US |
dc.contributor.author | Drake, BF | en_US |
dc.contributor.author | Vega, A | en_US |
dc.contributor.author | Gómez-Caamaño, A | en_US |
dc.contributor.author | Szulkin, R | en_US |
dc.contributor.author | Eklund, M | en_US |
dc.contributor.author | Kogevinas, M | en_US |
dc.contributor.author | Llorca, J | en_US |
dc.contributor.author | Castaño-Vinyals, G | en_US |
dc.contributor.author | Penney, KL | en_US |
dc.contributor.author | Stampfer, M | en_US |
dc.contributor.author | Park, JY | en_US |
dc.contributor.author | Sellers, TA | en_US |
dc.contributor.author | Lin, HY | en_US |
dc.contributor.author | Stanford, JL | en_US |
dc.contributor.author | Cybulski, C | en_US |
dc.date.available | 2018-04-05 | en_US |
dc.date.issued | 2018-07-01 | en_US |
dc.identifier.citation | Nature Genetics, 2018, 50 (7), pp. 928 - 936 | en_US |
dc.identifier.issn | 1061-4036 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/129550 | |
dc.description.abstract | © 2018 The Author(s). Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10-8) with PrCa and one locus significantly associated with early-onset PrCa (≤55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 × 10-9; G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa 1 . | en_US |
dc.relation.ispartof | Nature Genetics | en_US |
dc.relation.isbasedon | 10.1038/s41588-018-0142-8 | en_US |
dc.subject.classification | Developmental Biology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Prostatic Neoplasms | en_US |
dc.subject.mesh | Genetic Predisposition to Disease | en_US |
dc.subject.mesh | Risk | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Genotype | en_US |
dc.subject.mesh | Polymorphism, Single Nucleotide | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Genome-Wide Association Study | en_US |
dc.subject.mesh | Genetic Loci | en_US |
dc.title | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | en_US |
dc.type | Journal Article | |
utslib.citation.volume | 7 | en_US |
utslib.citation.volume | 50 | en_US |
utslib.for | 1112 Oncology and Carcinogenesis | en_US |
utslib.for | 1117 Public Health and Health Services | en_US |
utslib.for | 06 Biological Sciences | en_US |
utslib.for | 11 Medical and Health Sciences | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health | |
utslib.copyright.status | closed_access | |
pubs.issue | 7 | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 50 | en_US |
Abstract:
© 2018 The Author(s). Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10-8) with PrCa and one locus significantly associated with early-onset PrCa (≤55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 × 10-9; G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa 1 .
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