Combined effects of 3D bone marrow stem cell-seeded wet-electrospun poly lactic acid scaffolds on full-thickness skin wound healing

Ghorbani, S; Eyni, H; Tiraihi, T; Asl, LS; Soleimani, M; Atashi, A; Beiranvand, SP; Warkiani, ME

Combined effects of 3D bone marrow stem cell-seeded wet-electrospun poly lactic acid scaffolds on full-thickness skin wound healing

Ghorbani, S Eyni, H Tiraihi, T Asl, LS Soleimani, M Atashi, A Beiranvand, SP Warkiani, ME

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Publication Type:: Journal Article
Citation:: International Journal of Polymeric Materials and Polymeric Biomaterials, 2018, 67 (15), pp. 905 - 912
Issue Date:: 2018-01-01

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Field	Value	Language
dc.contributor.author	Ghorbani, S	en_US
dc.contributor.author	Eyni, H	en_US
dc.contributor.author	Tiraihi, T	en_US
dc.contributor.author	Asl, LS	en_US
dc.contributor.author	Soleimani, M	en_US
dc.contributor.author	Atashi, A	en_US
dc.contributor.author	Beiranvand, SP	en_US
dc.contributor.author	Warkiani, ME https://orcid.org/0000-0002-4184-1944	en_US
dc.date.issued	2018-01-01	en_US
dc.identifier.citation	International Journal of Polymeric Materials and Polymeric Biomaterials, 2018, 67 (15), pp. 905 - 912	en_US
dc.identifier.issn	0091-4037	en_US
dc.identifier.uri	http://hdl.handle.net/10453/130223
dc.description.abstract	© 2017 Taylor & Francis. Tissue engineering has emerged as an alternative treatment to traditional grafts for skin wound healing. Three-dimensional nanofibers have been used extensively for this purpose due to their excellent biomedical-related properties. In this study, high porous 3D poly lactic acid nanofibrous scaffolds (PLA-S) were prepared by wet-electrospinning technique and seeded with rat bone-marrow stem cells (BMSCs) to characterize the biocompatibility and therapeutic efficacy of these fibers on the treating full-thickness dermal wounds. The results of in vitro andin vivo studies indicate that the 3D fibrous PLA-S can be a potential wound dressing for wound repair, particularly when seeded with BMSCs. GRAPHICAL ABSTRACT.	en_US
dc.relation.ispartof	International Journal of Polymeric Materials and Polymeric Biomaterials	en_US
dc.relation.isbasedon	10.1080/00914037.2017.1393681	en_US
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Polymers	en_US
dc.title	Combined effects of 3D bone marrow stem cell-seeded wet-electrospun poly lactic acid scaffolds on full-thickness skin wound healing	en_US
dc.type	Journal Article
utslib.citation.volume	15	en_US
utslib.citation.volume	67	en_US
utslib.for	0303 Macromolecular and Materials Chemistry	en_US
utslib.for	0912 Materials Engineering	en_US
utslib.for	0903 Biomedical Engineering	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	09 Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access	*
pubs.issue	15	en_US
pubs.publication-status	Published	en_US
pubs.volume	67	en_US

Abstract:

© 2017 Taylor & Francis. Tissue engineering has emerged as an alternative treatment to traditional grafts for skin wound healing. Three-dimensional nanofibers have been used extensively for this purpose due to their excellent biomedical-related properties. In this study, high porous 3D poly lactic acid nanofibrous scaffolds (PLA-S) were prepared by wet-electrospinning technique and seeded with rat bone-marrow stem cells (BMSCs) to characterize the biocompatibility and therapeutic efficacy of these fibers on the treating full-thickness dermal wounds. The results of in vitro andin vivo studies indicate that the 3D fibrous PLA-S can be a potential wound dressing for wound repair, particularly when seeded with BMSCs. GRAPHICAL ABSTRACT.

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http://hdl.handle.net/10453/130223